Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder

Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these...

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Detalles Bibliográficos
Autores principales: Dunne, Margaret R., Byrne, Greg, Chirdo, Fernando Gabriel, Feighery, Conleth
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2020
Materias:
Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/119001
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-119001
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
spellingShingle Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
Dunne, Margaret R.
Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
topic_facet Biología
Coeliac disease
Pathogenesis
Enteropathy
Immunopathology
Innate and adaptive immune response
Molecular mechanisms of disease
description Coeliac disease is a common small bowel enteropathy arising in genetically predisposed individuals and caused by ingestion of gluten in the diet. Great advances have been made in understanding the role of the adaptive immune system in response to gluten peptides. Despite detailed knowledge of these adaptive immune mechanisms, the complete series of pathogenic events responsible for development of the tissue lesion remains less certain. This review contributes to the field by discussing additional mechanisms whichmay also contribute to pathogenesis. These include the production of cytokines such as interleukin-15 by intestinal epithelial cells and local antigen presenting cells as a pivotal event in the disease process. A subset of unconventional T cells called gamma/delta T cells are also persistently expanded in the coeliac disease (CD) small intestinal epithelium and recent analysis has shown that these cells contribute to pathogenic inflammation. Other unconventional T cell subsets may play a local immunoregulatory role and require further study. It has also been suggested that, in addition to activation of pathogenic T helper cells by gluten peptides, other peptides may directly interact with the intestinal mucosa, further contributing to the disease process.We also discuss how myofibroblasts, a major source of tissue transglutaminase and metalloproteases, may play a key role in intestinal tissue remodeling. Contribution of each of these factors to pathogenesis is discussed to enhance our view of this complex disorder and to contribute to a wider understanding of chronic immune- mediated disease.
format Articulo
Revision
author Dunne, Margaret R.
Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
author_facet Dunne, Margaret R.
Byrne, Greg
Chirdo, Fernando Gabriel
Feighery, Conleth
author_sort Dunne, Margaret R.
title Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_short Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_full Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_fullStr Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_full_unstemmed Coeliac Disease Pathogenesis: The Uncertainties of a Well-Known Immune Mediated Disorder
title_sort coeliac disease pathogenesis: the uncertainties of a well-known immune mediated disorder
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/119001
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