ATPe Dynamics in Protozoan Parasites: Adapt or Perish

In most animals, transient increases of extracellular ATP (ATPe) are used for physiological signaling or as a danger signal in pathological conditions. ATPe dynamics are controlled by ATP release from viable cells and cell lysis, ATPe degradation and interconversion by ecto-nucleotidases, and intera...

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Detalles Bibliográficos
Autores principales: Lauri, Natalia, Bazzi, Zaher, Álvarez, Cora L., Leal Denis, María F., Schachter, Julieta, Herlax, Vanesa Silvana, Ostuni, Mariano A., Schwarzbaum, Pablo J.
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Parasite
Membrane proteins
Host–parasite interaction
Transport
Pathogenesis
Evolution
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/118993
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-118993
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Parasite
Membrane proteins
Host–parasite interaction
Transport
Pathogenesis
Evolution
spellingShingle Ciencias Médicas
Parasite
Membrane proteins
Host–parasite interaction
Transport
Pathogenesis
Evolution
Lauri, Natalia
Bazzi, Zaher
Álvarez, Cora L.
Leal Denis, María F.
Schachter, Julieta
Herlax, Vanesa Silvana
Ostuni, Mariano A.
Schwarzbaum, Pablo J.
ATPe Dynamics in Protozoan Parasites: Adapt or Perish
topic_facet Ciencias Médicas
Parasite
Membrane proteins
Host–parasite interaction
Transport
Pathogenesis
Evolution
description In most animals, transient increases of extracellular ATP (ATPe) are used for physiological signaling or as a danger signal in pathological conditions. ATPe dynamics are controlled by ATP release from viable cells and cell lysis, ATPe degradation and interconversion by ecto-nucleotidases, and interaction of ATPe and byproducts with cell surface purinergic receptors and purine salvage mechanisms. Infection by protozoan parasites may alter at least one of the mechanisms controlling ATPe concentration. Protozoan parasites display their own set of proteins directly altering ATPe dynamics, or control the activity of host proteins. Parasite dependent activation of ATPe conduits of the host may promote infection and systemic responses that are beneficial or detrimental to the parasite. For instance, activation of organic solute permeability at the host membrane can support the elevated metabolism of the parasite. On the other hand ecto-nucleotidases of protozoan parasites, by promoting ATPe degradation and purine/pyrimidine salvage, may be involved in parasite growth, infectivity, and virulence. In this review, we will describe the complex dynamics of ATPe regulation in the context of protozoan parasite–host interactions. Particular focus will be given to features of parasite membrane proteins strongly controlling ATPe dynamics. This includes evolutionary, genetic and cellular mechanisms, as well as structural-functional relationships.
format Articulo
Revision
author Lauri, Natalia
Bazzi, Zaher
Álvarez, Cora L.
Leal Denis, María F.
Schachter, Julieta
Herlax, Vanesa Silvana
Ostuni, Mariano A.
Schwarzbaum, Pablo J.
author_facet Lauri, Natalia
Bazzi, Zaher
Álvarez, Cora L.
Leal Denis, María F.
Schachter, Julieta
Herlax, Vanesa Silvana
Ostuni, Mariano A.
Schwarzbaum, Pablo J.
author_sort Lauri, Natalia
title ATPe Dynamics in Protozoan Parasites: Adapt or Perish
title_short ATPe Dynamics in Protozoan Parasites: Adapt or Perish
title_full ATPe Dynamics in Protozoan Parasites: Adapt or Perish
title_fullStr ATPe Dynamics in Protozoan Parasites: Adapt or Perish
title_full_unstemmed ATPe Dynamics in Protozoan Parasites: Adapt or Perish
title_sort atpe dynamics in protozoan parasites: adapt or perish
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/118993
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