Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides

Herein we present the synthesis and structural analysis of novel -O-(N)-glycosides. The biphasic reaction of NHS and acetobromo-α-D-glucose or D-galactose gives the β anomer glycoside in a straightforward manner. Further hydrazinolysis and condensation with decanal afforded the desired products. The...

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Detalles Bibliográficos
Autores principales: Bejarano Rengel, Natividad, Lafuente, María Leticia, Esteche, Juliana, Santiago, Cintia C., Rojas, Agustín Hugo, Ponzinibbio, Agustín
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Química
Amphiphilic carbohydrates
-O-(N)-glycosides
NMR
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/118924
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
Descripción
Sumario:Herein we present the synthesis and structural analysis of novel -O-(N)-glycosides. The biphasic reaction of NHS and acetobromo-α-D-glucose or D-galactose gives the β anomer glycoside in a straightforward manner. Further hydrazinolysis and condensation with decanal afforded the desired products. Their complete structures, including the anomeric and E/Z double bond configurations, were determined by spectroscopic analysis.

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