Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides

Herein we present the synthesis and structural analysis of novel -O-(N)-glycosides. The biphasic reaction of NHS and acetobromo-α-D-glucose or D-galactose gives the β anomer glycoside in a straightforward manner. Further hydrazinolysis and condensation with decanal afforded the desired products. The...

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Detalles Bibliográficos
Autores principales: Bejarano Rengel, Natividad, Lafuente, María Leticia, Esteche, Juliana, Santiago, Cintia C., Rojas, Agustín Hugo, Ponzinibbio, Agustín
Formato: Articulo
Lenguaje:Inglés
Publicado: 2020
Materias:
Química
Amphiphilic carbohydrates
-O-(N)-glycosides
NMR
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/118924
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-118924
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Amphiphilic carbohydrates
-O-(N)-glycosides
NMR
spellingShingle Química
Amphiphilic carbohydrates
-O-(N)-glycosides
NMR
Bejarano Rengel, Natividad
Lafuente, María Leticia
Esteche, Juliana
Santiago, Cintia C.
Rojas, Agustín Hugo
Ponzinibbio, Agustín
Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
topic_facet Química
Amphiphilic carbohydrates
-O-(N)-glycosides
NMR
description Herein we present the synthesis and structural analysis of novel -O-(N)-glycosides. The biphasic reaction of NHS and acetobromo-α-D-glucose or D-galactose gives the β anomer glycoside in a straightforward manner. Further hydrazinolysis and condensation with decanal afforded the desired products. Their complete structures, including the anomeric and E/Z double bond configurations, were determined by spectroscopic analysis.
format Articulo
Articulo
author Bejarano Rengel, Natividad
Lafuente, María Leticia
Esteche, Juliana
Santiago, Cintia C.
Rojas, Agustín Hugo
Ponzinibbio, Agustín
author_facet Bejarano Rengel, Natividad
Lafuente, María Leticia
Esteche, Juliana
Santiago, Cintia C.
Rojas, Agustín Hugo
Ponzinibbio, Agustín
author_sort Bejarano Rengel, Natividad
title Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
title_short Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
title_full Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
title_fullStr Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
title_full_unstemmed Synthesis and Structure of Novel Potentially Bioactive Amphiphilic -O-(N)-Glycosides
title_sort synthesis and structure of novel potentially bioactive amphiphilic -o-(n)-glycosides
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/118924
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