Participation of NO in the vasodilatory action of isoespintanol
Background: Accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Met...
| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2019
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/117279 |
| Aporte de: |
| id |
I19-R120-10915-117279 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Isoespintanol Rhoracic aorta Nitric oxide Isoespintanol Aorta Torácica Óxido nítrico |
| spellingShingle |
Ciencias Médicas Isoespintanol Rhoracic aorta Nitric oxide Isoespintanol Aorta Torácica Óxido nítrico Rinaldi, Gustavo Rojano, Benjamín Schinella, Guillermo Raúl Mosca, Susana María Participation of NO in the vasodilatory action of isoespintanol |
| topic_facet |
Ciencias Médicas Isoespintanol Rhoracic aorta Nitric oxide Isoespintanol Aorta Torácica Óxido nítrico |
| description |
Background: Accumulating evidence suggests that natural compounds and specifically monoterpenes exert a vasodilator action. Objetive: to investigate the vascular effects of isoespintanol (2-isopropil-3,6- dimetoxi-5-metilfenol, ISO) monoterpene isolated from the leaves of Oxandra cf xylopioides. Methods: thoracic aortic rings isolated from Wistar rats were contracted with KCl 80 mM and then relaxed by exposure to Ca2+-free solution in absence and in presence of ISO 0.6 mg/mL. The force/tissue ratio (F/W) and the time to obtain 50% of relaxation (T-50) were used to assess the maximal contractile response and the relaxation, respectively. To examine the participation of NO additional experiments were performed under inhibition of nitric oxide synthase with L-NAME (L-NG-Nitroarginine methyl ester). Results: ISO significantly decreased the F/W ratio (257 ± 19 vs. 360 ± 18) and did not change T-50. In presence of L-NAME the effects of ISO on contractile response was abolished. Conclusions: these results demonstrate that ISO exerts a vasodilator effect through NO-dependent pathways and suggest that an inhibition of calcium influx could be the involved mechanism. |
| format |
Articulo Articulo |
| author |
Rinaldi, Gustavo Rojano, Benjamín Schinella, Guillermo Raúl Mosca, Susana María |
| author_facet |
Rinaldi, Gustavo Rojano, Benjamín Schinella, Guillermo Raúl Mosca, Susana María |
| author_sort |
Rinaldi, Gustavo |
| title |
Participation of NO in the vasodilatory action of isoespintanol |
| title_short |
Participation of NO in the vasodilatory action of isoespintanol |
| title_full |
Participation of NO in the vasodilatory action of isoespintanol |
| title_fullStr |
Participation of NO in the vasodilatory action of isoespintanol |
| title_full_unstemmed |
Participation of NO in the vasodilatory action of isoespintanol |
| title_sort |
participation of no in the vasodilatory action of isoespintanol |
| publishDate |
2019 |
| url |
http://sedici.unlp.edu.ar/handle/10915/117279 |
| work_keys_str_mv |
AT rinaldigustavo participationofnointhevasodilatoryactionofisoespintanol AT rojanobenjamin participationofnointhevasodilatoryactionofisoespintanol AT schinellaguillermoraul participationofnointhevasodilatoryactionofisoespintanol AT moscasusanamaria participationofnointhevasodilatoryactionofisoespintanol AT rinaldigustavo participaciondenoenlaaccionvasodilatadoradelisoespintanol AT rojanobenjamin participaciondenoenlaaccionvasodilatadoradelisoespintanol AT schinellaguillermoraul participaciondenoenlaaccionvasodilatadoradelisoespintanol AT moscasusanamaria participaciondenoenlaaccionvasodilatadoradelisoespintanol |
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Repositorios |
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1764820447184027648 |