Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure

Chlorogenic acid (ChlA) has shown short-term protective effects against the cytogenotoxic effects of ochratoxin A (OTA). The present study evaluated the effect of oral administration of ChlA in male Wistar rats exposed to OTA. OTA (0.4 mg/kg bw/ day), ChlA (5 mg/kg bw/day), or the combination of bot...

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Detalles Bibliográficos
Autores principales: Campra, Noelia Anahí, Cariddi, Laura Noelia, Escobar, Franco Matías, Sabini, María Carola, Freire-de-Lima, Celio Geraldo, Decote-Ricardo, Debora, Roma, Dardo, Mañas, Fernando, Dalcero, Ana María
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2020
Materias:
Ciencias Veterinarias
Ochratoxin A
Ocratoxina A
Genotoxicity
Genotoxicidad
Chlorogenic acid
Ácido Clorogénico
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/115704
https://revistas.unlp.edu.ar/analecta/article/view/10063
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-115704
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Ochratoxin A
Ocratoxina A
Genotoxicity
Genotoxicidad
Chlorogenic acid
Ácido Clorogénico
spellingShingle Ciencias Veterinarias
Ochratoxin A
Ocratoxina A
Genotoxicity
Genotoxicidad
Chlorogenic acid
Ácido Clorogénico
Campra, Noelia Anahí
Cariddi, Laura Noelia
Escobar, Franco Matías
Sabini, María Carola
Freire-de-Lima, Celio Geraldo
Decote-Ricardo, Debora
Roma, Dardo
Mañas, Fernando
Dalcero, Ana María
Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
topic_facet Ciencias Veterinarias
Ochratoxin A
Ocratoxina A
Genotoxicity
Genotoxicidad
Chlorogenic acid
Ácido Clorogénico
description Chlorogenic acid (ChlA) has shown short-term protective effects against the cytogenotoxic effects of ochratoxin A (OTA). The present study evaluated the effect of oral administration of ChlA in male Wistar rats exposed to OTA. OTA (0.4 mg/kg bw/ day), ChlA (5 mg/kg bw/day), or the combination of both, were administered orally to animals during 28 days. No deaths, decrease in feed consumption or change in the body weight of animals were observed in any group. In the OTA-treated group a decrease in locomotion as well as increased DNA damage in blood, kidney and bone marrow cells were observed. ChlA alone was not genotoxic for animals. The combination of OTA +ChlA decreased the DNA damage by 37% in blood cells, by 55% in kidney cells and by 80% in bone marrow cells compared to OTA-treated group. In conclusion, oral treatment with ChlA showed a good protective effect on genotoxicity produced by OTA in rats during 28 days exposure.
format Articulo
Comunicacion
author Campra, Noelia Anahí
Cariddi, Laura Noelia
Escobar, Franco Matías
Sabini, María Carola
Freire-de-Lima, Celio Geraldo
Decote-Ricardo, Debora
Roma, Dardo
Mañas, Fernando
Dalcero, Ana María
author_facet Campra, Noelia Anahí
Cariddi, Laura Noelia
Escobar, Franco Matías
Sabini, María Carola
Freire-de-Lima, Celio Geraldo
Decote-Ricardo, Debora
Roma, Dardo
Mañas, Fernando
Dalcero, Ana María
author_sort Campra, Noelia Anahí
title Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
title_short Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
title_full Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
title_fullStr Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
title_full_unstemmed Protective role of chlorogenic acid on DNA damage caused by ochratoxin A exposure
title_sort protective role of chlorogenic acid on dna damage caused by ochratoxin a exposure
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/115704
https://revistas.unlp.edu.ar/analecta/article/view/10063
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