Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina

To identify the changes in the lipid profile of the tear film in two human populations exposed to different levels of particulate material, and its relationship with dry eye, by gas chromatography with mass spectrometry (GC-MS) detection. A panel study involving 78 volunteers, who live and work in t...

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Autores principales: Gutiérrez, María de los Ángeles, Colman Lerner, Jorge Esteban, Giuliani, Daniela Silvana, Porta, Atilio Andrés, Andrinolo, Darío
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Química
PM
Lipid composition
Tears
Fatty acids
Dry eye
Environmental
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/113415
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-113415
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
PM
Lipid composition
Tears
Fatty acids
Dry eye
Environmental
spellingShingle Química
PM
Lipid composition
Tears
Fatty acids
Dry eye
Environmental
Gutiérrez, María de los Ángeles
Colman Lerner, Jorge Esteban
Giuliani, Daniela Silvana
Porta, Atilio Andrés
Andrinolo, Darío
Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
topic_facet Química
PM
Lipid composition
Tears
Fatty acids
Dry eye
Environmental
description To identify the changes in the lipid profile of the tear film in two human populations exposed to different levels of particulate material, and its relationship with dry eye, by gas chromatography with mass spectrometry (GC-MS) detection. A panel study involving 78 volunteers, who live and work in two locations in Argentina with different pollution levels: urban zone (n = 44) and industrial zone (n = 34). We measured the mean levels of particulate matter (PM) exposure. The tear samples were analyze by gas GC-MS detection and the dry eye was diagnose using Schirmer test, fluorescein breakup time, vital staining with fluorescein and lissamine green, and lid parallel conjunctival folds (LIPCOF). Statistical analysis was performed using Chi-Square, Bartlett’s, Mann-Whitney tests, and Multiple Correspondence Analysis. PM10 level was significantly higher in industrial zone than in urban area (p < 0.05). Subjects exposed to higher levels of PM10 in outdoor air presented more presence of fatty acids (FA) of long chain, a higher proportion of saturated fatty acids (SFA), and lower unsaturated fatty acids (UFA), showing a differentiated profile, which may be associated with a PM level. The incidence of dry eye was greater in the industrial zone (p < 0.001), showing in both populations for this pathology higher FA ω-6 levels, which are responsible for the inflammation process. The lipid profile in populations exposed to higher levels of PM10, like the industrial zone, shows a differentiated profile of FA and more incidence of dry eye with higher FA ω-6 levels, which are responsible for the inflammation process.
format Articulo
Articulo
author Gutiérrez, María de los Ángeles
Colman Lerner, Jorge Esteban
Giuliani, Daniela Silvana
Porta, Atilio Andrés
Andrinolo, Darío
author_facet Gutiérrez, María de los Ángeles
Colman Lerner, Jorge Esteban
Giuliani, Daniela Silvana
Porta, Atilio Andrés
Andrinolo, Darío
author_sort Gutiérrez, María de los Ángeles
title Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
title_short Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
title_full Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
title_fullStr Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
title_full_unstemmed Comparative study of tear lipid composition in two human populations with different exposure to particulate matter in La Plata, Argentina
title_sort comparative study of tear lipid composition in two human populations with different exposure to particulate matter in la plata, argentina
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/113415
work_keys_str_mv AT gutierrezmariadelosangeles comparativestudyoftearlipidcompositionintwohumanpopulationswithdifferentexposuretoparticulatematterinlaplataargentina
AT colmanlernerjorgeesteban comparativestudyoftearlipidcompositionintwohumanpopulationswithdifferentexposuretoparticulatematterinlaplataargentina
AT giulianidanielasilvana comparativestudyoftearlipidcompositionintwohumanpopulationswithdifferentexposuretoparticulatematterinlaplataargentina
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AT andrinolodario comparativestudyoftearlipidcompositionintwohumanpopulationswithdifferentexposuretoparticulatematterinlaplataargentina
bdutipo_str Repositorios
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