Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions
Magnetic hyperthermia, a modality that uses radio frequency heating assisted with single-domain magnetic nanoparticles, is becoming established as a powerful oncological therapy. Much improvement in nanomaterials development, to enhance their heating efficiency by tuning the magnetic colloidal prope...
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| Autores principales: | , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2017
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/109306 https://pubs.rsc.org/en/content/articlelanding/2017/CP/C6CP08059F |
| Aporte de: |
| id |
I19-R120-10915-109306 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Física hyperthermic performances magnetic colloids oncological therapy |
| spellingShingle |
Ciencias Exactas Física hyperthermic performances magnetic colloids oncological therapy Fernández van Raap, Marcela Beatriz Coral Coral, Diego Fernando Yu, S. Muñoz Medina, Guillermo Arturo Sánchez, Francisco Homero Roig, A. Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| topic_facet |
Ciencias Exactas Física hyperthermic performances magnetic colloids oncological therapy |
| description |
Magnetic hyperthermia, a modality that uses radio frequency heating assisted with single-domain magnetic nanoparticles, is becoming established as a powerful oncological therapy. Much improvement in nanomaterials development, to enhance their heating efficiency by tuning the magnetic colloidal properties, has been achieved. However, methodological standardization to accurately and univocally determine the colloidal properties required to numerically reproduce a specific heating efficiency using analytical expressions still holds. Thus, anticipating the hyperthermic performances of magnetic colloids entails high complexity due to polydispersity, aggregation and dipolar interactions always present in real materials to a greater or lesser degree. Here, by numerically simulating the experimental results and using real biomedical aqueous colloids, we analyse and compare several approaches to reproduce experimental specific absorption rate values. Then, we show that the relaxation time, determined using a representative mean activation energy consistently derived from four independent experiments accurately reproduces experimental heating efficiencies. Moreover, the so-derived relaxation time can be used to extrapolate the heating performance of the magnetic nanoparticles to the other field conditions within the framework of the linear response theory. We thus present a practical tool that may truly aid the design of medical decisions. |
| format |
Articulo Articulo |
| author |
Fernández van Raap, Marcela Beatriz Coral Coral, Diego Fernando Yu, S. Muñoz Medina, Guillermo Arturo Sánchez, Francisco Homero Roig, A. |
| author_facet |
Fernández van Raap, Marcela Beatriz Coral Coral, Diego Fernando Yu, S. Muñoz Medina, Guillermo Arturo Sánchez, Francisco Homero Roig, A. |
| author_sort |
Fernández van Raap, Marcela Beatriz |
| title |
Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| title_short |
Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| title_full |
Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| title_fullStr |
Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| title_full_unstemmed |
Anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| title_sort |
anticipating hyperthermic efficiency of magnetic colloids using a semi-empirical model: a tool to help medical decisions |
| publishDate |
2017 |
| url |
http://sedici.unlp.edu.ar/handle/10915/109306 https://pubs.rsc.org/en/content/articlelanding/2017/CP/C6CP08059F |
| work_keys_str_mv |
AT fernandezvanraapmarcelabeatriz anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions AT coralcoraldiegofernando anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions AT yus anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions AT munozmedinaguillermoarturo anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions AT sanchezfranciscohomero anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions AT roiga anticipatinghyperthermicefficiencyofmagneticcolloidsusingasemiempiricalmodelatooltohelpmedicaldecisions |
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Repositorios |
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1764820443742601219 |