Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico

Background: Syphilis remains a public health concern worldwide, the accuracy of diagnostic tests is critical for its successful control. Currently, there are two approaches to the diagnosis of syphilis using serological tests: the traditional algorithm and the reverse algorithm. Aim: The goal of th...

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Autores principales: Martínez Methol, María Soledad, Ventimiglia, Fernando Daniel, Aristimuño, Ana M., Colina, Amelia N. de la, Bruno, Jorge J., D’Agostino, Liliana E.
Formato: Articulo
Lenguaje:Español
Publicado: 2019
Materias:
Bioquímica
Syphilis
Reverse algorithm for syphilis
Treponemal chemiluminescence immunoassay
Sífilis
Algoritmo reverso para sífilis
Inmunoensayo treponémico quimioluminiscente
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/109201
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-109201
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Bioquímica
Syphilis
Reverse algorithm for syphilis
Treponemal chemiluminescence immunoassay
Sífilis
Algoritmo reverso para sífilis
Inmunoensayo treponémico quimioluminiscente
spellingShingle Bioquímica
Syphilis
Reverse algorithm for syphilis
Treponemal chemiluminescence immunoassay
Sífilis
Algoritmo reverso para sífilis
Inmunoensayo treponémico quimioluminiscente
Martínez Methol, María Soledad
Ventimiglia, Fernando Daniel
Aristimuño, Ana M.
Colina, Amelia N. de la
Bruno, Jorge J.
D’Agostino, Liliana E.
Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
topic_facet Bioquímica
Syphilis
Reverse algorithm for syphilis
Treponemal chemiluminescence immunoassay
Sífilis
Algoritmo reverso para sífilis
Inmunoensayo treponémico quimioluminiscente
description Background: Syphilis remains a public health concern worldwide, the accuracy of diagnostic tests is critical for its successful control. Currently, there are two approaches to the diagnosis of syphilis using serological tests: the traditional algorithm and the reverse algorithm. Aim: The goal of this study was to analyse the advantages and disadvantages in the implementation of the syphilis reverse-screening algorithm in an outpatient clinical laboratory. Methods: An observational cross-sectional study was carried out analyzing 246 reactive sera from a total of 14700 requests for syphilis serology. Chemiluminescent assay ARCHITECT Syphilis TP, V.D.R.L. and FTA-Abs were performed. Results: Among 246 reactive sera by ARCHITECT Syphilis TP, 129 were reactive and 117 were non-reactive by V.D.R.L. the last mentioned resulted in 97 reactive and 20 non-reactive by FTA-Abs, suggesting false positives (0.13%).Two patients with primary infection were detected, that were not detected by V.D.R.L. and one pregnant woman with primary infection with a high value S/CO and V.D.R.L.:1 dils. Conclusions: Among the advantages of using a reverse algorithm were greater sensitivity in the detection of patients with primary syphilis; automation, complete traceability of the samples; objective interpretation and conclusive results.
format Articulo
Articulo
author Martínez Methol, María Soledad
Ventimiglia, Fernando Daniel
Aristimuño, Ana M.
Colina, Amelia N. de la
Bruno, Jorge J.
D’Agostino, Liliana E.
author_facet Martínez Methol, María Soledad
Ventimiglia, Fernando Daniel
Aristimuño, Ana M.
Colina, Amelia N. de la
Bruno, Jorge J.
D’Agostino, Liliana E.
author_sort Martínez Methol, María Soledad
title Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
title_short Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
title_full Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
title_fullStr Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
title_full_unstemmed Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
title_sort implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/109201
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