Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media
Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy c...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Conjunto de datos |
| Lenguaje: | Inglés |
| Publicado: |
2020
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/109060 https://doi.org/10.35537/10915/109060 |
| Aporte de: |
| id |
I19-R120-10915-109060 |
|---|---|
| record_format |
dspace |
| spelling |
I19-R120-10915-1090602023-04-27T15:09:32Z http://sedici.unlp.edu.ar/handle/10915/109060 https://doi.org/10.35537/10915/109060 Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G. 2020-11-13T17:39:33Z 2017 en Ciencias Exactas Química https://purl.org/becyt/ford/1.4 mononuclear structures biological interactions Pd(II) complex Pt(II) complex Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents. Fil: Balsa, Lucía Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina. Fil: León, Ignacio Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino";Argentina Fil: León, Ignacio Esteban. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: Ruiz, María Carolina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica; Argentina Facultad de Ciencias Exactas Centro de Química Inorgánica Conjunto de datos Conjunto de datos http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) application/octet-stream Data were collected on a Bruker Kappa Apex II diffractometer. The software package SHELXTL was used for space group determination, structure solution, and refinement. The structure was solved by direct methods, completed with difference Fourier syntheses, and refined with anisotropic displacement parameters. |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Química https://purl.org/becyt/ford/1.4 mononuclear structures biological interactions Pd(II) complex Pt(II) complex |
| spellingShingle |
Ciencias Exactas Química https://purl.org/becyt/ford/1.4 mononuclear structures biological interactions Pd(II) complex Pt(II) complex Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G. Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| topic_facet |
Ciencias Exactas Química https://purl.org/becyt/ford/1.4 mononuclear structures biological interactions Pd(II) complex Pt(II) complex |
| description |
Two Pd(II) and Pt(II) complexes with two pyrrol-2-carbaldehyde N-p-chlorophenylthiosemicarbazone ligands are designed and characterized showing mononuclear structures. An important pharmacological property for both compounds is the high selectivity for tumor cells and a lack of activity in healthy cells. The Pd(II) compound shows a higher antitumor activity and selectivity than the Pt(II) compound. Both complexes present a variety of biological interactions: with DNA models (pBR322 and CT DNA), proteins (lysozyme and RNase) and other biological targets like proteosome. Our results show that the Pd(II) complex is a more interesting candidate for potential anticancer therapies than the Pt(II) complex, and we provide new insight into the design and synthesis of palladium compounds as potential antitumor agents. |
| format |
Conjunto de datos Conjunto de datos |
| author |
Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G. |
| author_facet |
Matesanz, Ana I. Jimenez Faraco, Eva Ruiz, María Carolina Balsa, Lucía Mariana Navarro Ranninger, Carmen León, Ignacio Esteban Quiroga, Adoración G. |
| author_sort |
Matesanz, Ana I. |
| title |
Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| title_short |
Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| title_full |
Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| title_fullStr |
Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| title_full_unstemmed |
Data from: Mononuclear Pd(II) and Pt(II) complexes with an α-N-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| title_sort |
data from: mononuclear pd(ii) and pt(ii) complexes with an α-n-heterocyclic thiosemicarbazone: cytotoxicity, solution behaviour and interaction <i>versus</i> proven models from biological media |
| publishDate |
2020 |
| url |
http://sedici.unlp.edu.ar/handle/10915/109060 https://doi.org/10.35537/10915/109060 |
| work_keys_str_mv |
AT matesanzanai datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT jimenezfaracoeva datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT ruizmariacarolina datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT balsaluciamariana datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT navarroranningercarmen datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT leonignacioesteban datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia AT quirogaadoraciong datafrommononuclearpdiiandptiicomplexeswithananheterocyclicthiosemicarbazonecytotoxicitysolutionbehaviourandinteractioniversusiprovenmodelsfrombiologicalmedia |
| _version_ |
1765659801527779328 |