A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line

The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</...

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Detalles Bibliográficos
Autores principales:	León, Ignacio Esteban, Parajón Costa, Beatriz Susana, Franca, Carlos Alberto, Etcheverry, Susana Beatriz, Baran, Enrique José
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2015
Materias:	Ciencias Exactas Química Oxidovanadium(IV) Oxodiacetic acid Dppz DFT calculations FTIR spectrum Electronic spectrum Human osteosarcoma cell line
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/108517
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

Descripción
Sumario:	The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.