A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line

The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</...

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Detalles Bibliográficos
Autores principales: León, Ignacio Esteban, Parajón Costa, Beatriz Susana, Franca, Carlos Alberto, Etcheverry, Susana Beatriz, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/108517
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-108517
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
spellingShingle Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
León, Ignacio Esteban
Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
topic_facet Ciencias Exactas
Química
Oxidovanadium(IV)
Oxodiacetic acid
Dppz
DFT calculations
FTIR spectrum
Electronic spectrum
Human osteosarcoma cell line
description The oxidovanadium(IV) complex of oxodiacetic acid (H<sub>2</sub>ODA) and dppz (dipyrido[3,2-a:2′,3′-c] phenazine) of stoichiometry [VO(ODA)(dppz)]⋅3H<sub>2</sub>O could be synthesized for the first time by reaction between [VO(ODA)(H<sub>2</sub>O)<sub>2</sub>] and dppz. It was characterized by infrared and electronic spectroscopies. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for crystallographic studies. The antitumor action of the complex on MG-63 human osteosarcoma cell line was also investigated. It was found that it caused a concentration-related inhibitory effect in the concentration range between 5 and 25 μM and diminished the cell viability ca. 45 % in the range from 25 to 100 μM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)(ophen)]⋅1.5H<sub>2</sub>O complex.
format Articulo
Articulo
author León, Ignacio Esteban
Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
author_facet León, Ignacio Esteban
Parajón Costa, Beatriz Susana
Franca, Carlos Alberto
Etcheverry, Susana Beatriz
Baran, Enrique José
author_sort León, Ignacio Esteban
title A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_short A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_full A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_fullStr A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_full_unstemmed A New Oxidovanadium(IV) Complex of Oxodiacetic Acid and dppz : Spectroscopic and DFT Study. Antitumor Action on MG-63 Human Osteosarcoma Cell Line
title_sort new oxidovanadium(iv) complex of oxodiacetic acid and dppz : spectroscopic and dft study. antitumor action on mg-63 human osteosarcoma cell line
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/108517
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