Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods
Background: Insects operate complex humoral and cellular immune strategies to fend against invading microorganisms. The majority of these have been characterized in Drosophila and other dipterans. Information on hemipterans, including Triatominae vectors of Chagas disease remains incomplete and frac...
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| Autores principales: | , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
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2018
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/108126 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5778769&blobtype=pdf |
| Aporte de: |
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I19-R120-10915-108126 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Exactas Innate immunity Hemipterans Triatomines Holometabolous Hemimetabolous Imd pathway |
| spellingShingle |
Ciencias Exactas Innate immunity Hemipterans Triatomines Holometabolous Hemimetabolous Imd pathway Zumaya Estrada, Federico Alonso Martínez Barnetche, Jesús Lavore, Andrés E. Rivera Pomar, Rolando Víctor Rodríguez, Mario Henry Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| topic_facet |
Ciencias Exactas Innate immunity Hemipterans Triatomines Holometabolous Hemimetabolous Imd pathway |
| description |
Background: Insects operate complex humoral and cellular immune strategies to fend against invading microorganisms. The majority of these have been characterized in Drosophila and other dipterans. Information on hemipterans, including Triatominae vectors of Chagas disease remains incomplete and fractionated.
Results: We identified putative immune-related homologs of three Triatominae vectors of Chagas disease, Triatoma pallidipennis, T. dimidiata and T. infestans (TTTs), using comparative transcriptomics based on established immune response gene references, in conjunction with the predicted proteomes of Rhodnius prolixus, Cimex lecticularis and Acyrthosiphon pisum hemimetabolous. We present a compressive description of the humoral and cellular innate immune components of these TTTs and extend the immune information of other related hemipterans. Key homologs of the constitutive and induced immunity genes were identified in all the studied hemipterans.
Conclusions: Our results in the TTTs extend previous observations in other hemipterans lacking several components of the Imd signaling pathway. Comparison with other hexapods, using published data, revealed that the absence of various Imd canonical components is common in several hemimetabolous species. |
| format |
Articulo Articulo |
| author |
Zumaya Estrada, Federico Alonso Martínez Barnetche, Jesús Lavore, Andrés E. Rivera Pomar, Rolando Víctor Rodríguez, Mario Henry |
| author_facet |
Zumaya Estrada, Federico Alonso Martínez Barnetche, Jesús Lavore, Andrés E. Rivera Pomar, Rolando Víctor Rodríguez, Mario Henry |
| author_sort |
Zumaya Estrada, Federico Alonso |
| title |
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| title_short |
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| title_full |
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| title_fullStr |
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| title_full_unstemmed |
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods |
| title_sort |
comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of imd canonical components among hemimetabolous arthropods |
| publishDate |
2018 |
| url |
http://sedici.unlp.edu.ar/handle/10915/108126 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5778769&blobtype=pdf |
| work_keys_str_mv |
AT zumayaestradafedericoalonso comparativegenomicsanalysisoftriatominesrevealscommonfirstlineandinducibleimmunityrelatedgenesandtheabsenceofimdcanonicalcomponentsamonghemimetabolousarthropods AT martinezbarnetchejesus comparativegenomicsanalysisoftriatominesrevealscommonfirstlineandinducibleimmunityrelatedgenesandtheabsenceofimdcanonicalcomponentsamonghemimetabolousarthropods AT lavoreandrese comparativegenomicsanalysisoftriatominesrevealscommonfirstlineandinducibleimmunityrelatedgenesandtheabsenceofimdcanonicalcomponentsamonghemimetabolousarthropods AT riverapomarrolandovictor comparativegenomicsanalysisoftriatominesrevealscommonfirstlineandinducibleimmunityrelatedgenesandtheabsenceofimdcanonicalcomponentsamonghemimetabolousarthropods AT rodriguezmariohenry comparativegenomicsanalysisoftriatominesrevealscommonfirstlineandinducibleimmunityrelatedgenesandtheabsenceofimdcanonicalcomponentsamonghemimetabolousarthropods |
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Repositorios |
| _version_ |
1764820444048785411 |