Activation of RyR2 by class I kinase inhibitors
Kinase inhibitors are a common treatment for cancer. Class I kinase inhibitors that target the ATP-binding pocket are particularly prevalent. Many of these compounds are cardiotoxic and can cause arrhythmias. Spontaneous release of Ca2+ via cardiac ryanodine receptors (RyR2), through a process terme...
Guardado en:
| Autores principales: | , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Español |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/108114 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6393232&blobtype=pdf |
| Aporte de: |
| id |
I19-R120-10915-108114 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Español |
| topic |
Ciencias Médicas |
| spellingShingle |
Ciencias Médicas Chakraborty, A. D. Gonano, Luis Alberto Munro, M. L. Smith, L. J, Thekkedam, C. Staudacher, V. Gamble, A. B. Macquaide, N. Dulhunty, A. F. Jones, P. P. Activation of RyR2 by class I kinase inhibitors |
| topic_facet |
Ciencias Médicas |
| description |
Kinase inhibitors are a common treatment for cancer. Class I kinase inhibitors that target the ATP-binding pocket are particularly prevalent. Many of these compounds are cardiotoxic and can cause arrhythmias. Spontaneous release of Ca2+ via cardiac ryanodine receptors (RyR2), through a process termed store overload-induced Ca2+ release (SOICR), is a common mechanism underlying arrhythmia. We explored whether class I kinase inhibitors could modify the activity of RyR2 and trigger SOICR to determine if this contributes to the cardiotoxic nature of these compounds. |
| format |
Articulo Articulo |
| author |
Chakraborty, A. D. Gonano, Luis Alberto Munro, M. L. Smith, L. J, Thekkedam, C. Staudacher, V. Gamble, A. B. Macquaide, N. Dulhunty, A. F. Jones, P. P. |
| author_facet |
Chakraborty, A. D. Gonano, Luis Alberto Munro, M. L. Smith, L. J, Thekkedam, C. Staudacher, V. Gamble, A. B. Macquaide, N. Dulhunty, A. F. Jones, P. P. |
| author_sort |
Chakraborty, A. D. |
| title |
Activation of RyR2 by class I kinase inhibitors |
| title_short |
Activation of RyR2 by class I kinase inhibitors |
| title_full |
Activation of RyR2 by class I kinase inhibitors |
| title_fullStr |
Activation of RyR2 by class I kinase inhibitors |
| title_full_unstemmed |
Activation of RyR2 by class I kinase inhibitors |
| title_sort |
activation of ryr2 by class i kinase inhibitors |
| publishDate |
2019 |
| url |
http://sedici.unlp.edu.ar/handle/10915/108114 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6393232&blobtype=pdf |
| work_keys_str_mv |
AT chakrabortyad activationofryr2byclassikinaseinhibitors AT gonanoluisalberto activationofryr2byclassikinaseinhibitors AT munroml activationofryr2byclassikinaseinhibitors AT smithlj activationofryr2byclassikinaseinhibitors AT thekkedamc activationofryr2byclassikinaseinhibitors AT staudacherv activationofryr2byclassikinaseinhibitors AT gambleab activationofryr2byclassikinaseinhibitors AT macquaiden activationofryr2byclassikinaseinhibitors AT dulhuntyaf activationofryr2byclassikinaseinhibitors AT jonespp activationofryr2byclassikinaseinhibitors |
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Repositorios |
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1764820444036202496 |