Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>

Sera of mice chronically infected with Trypanosoma cruzi contain antibodies that bind to the surface of living adult syngeneic heart muscle cells. In a syngeneic system, with nonadherent spleen mononuclear cells as effector cells and cardiocytes as targets, antibody-dependent cytotoxicity (ADCC), re...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Laguens, Rubén Martín, Cabeza Meckert, Patricia, Chambó, Jorge Guillermo
Formato: Articulo
Lenguaje:Inglés
Publicado: 1988
Materias:
Ciencias Médicas
Trypanosoma cruzi
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/108002
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC259404&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-108002
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Trypanosoma cruzi
spellingShingle Ciencias Médicas
Trypanosoma cruzi
Laguens, Rubén Martín
Cabeza Meckert, Patricia
Chambó, Jorge Guillermo
Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
topic_facet Ciencias Médicas
Trypanosoma cruzi
description Sera of mice chronically infected with Trypanosoma cruzi contain antibodies that bind to the surface of living adult syngeneic heart muscle cells. In a syngeneic system, with nonadherent spleen mononuclear cells as effector cells and cardiocytes as targets, antibody-dependent cytotoxicity (ADCC), revealed by the liberation of creatine phosphokinase from damaged cardiocytes, was observed after incorporation of serum samples from infected mice. Target damage was decreased after absorption with syngeneic myocardium, but absorption with T. cruzi epimastigotes or trypomastigotes or with syngeneic skeletal muscle had no effect on ADCC. No complement-dependent lysis against heart muscle cells was detected in the same serum samples. These observations indicate that serum from chronically chagasic mice contain antibodies that bind to the surface of living adult syngeneic cardiocytes and are able to exert ADCC, suggesting that they could play a role in the pathogenesis of the heart damage that occurs in Chagas' disease.
format Articulo
Articulo
author Laguens, Rubén Martín
Cabeza Meckert, Patricia
Chambó, Jorge Guillermo
author_facet Laguens, Rubén Martín
Cabeza Meckert, Patricia
Chambó, Jorge Guillermo
author_sort Laguens, Rubén Martín
title Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
title_short Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
title_full Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
title_fullStr Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
title_full_unstemmed Antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>Trypanosoma cruzi</i>
title_sort antiheart antibody-dependent cytotoxicity in the sera of mice chronically infected with <i>trypanosoma cruzi</i>
publishDate 1988
url http://sedici.unlp.edu.ar/handle/10915/108002
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC259404&blobtype=pdf
work_keys_str_mv AT laguensrubenmartin antiheartantibodydependentcytotoxicityintheseraofmicechronicallyinfectedwithitrypanosomacruzii
AT cabezameckertpatricia antiheartantibodydependentcytotoxicityintheseraofmicechronicallyinfectedwithitrypanosomacruzii
AT chambojorgeguillermo antiheartantibodydependentcytotoxicityintheseraofmicechronicallyinfectedwithitrypanosomacruzii
bdutipo_str Repositorios
_version_ 1764820443885207554

Ejemplares similares