Unbalance Between Sarcoplasmic Reticulum Ca2+ Uptake and Release: A First Step Toward Ca2+ Triggered Arrhythmias and Cardiac Damage

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling proteins involved in SR Ca2+ uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or...

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Detalles Bibliográficos
Autores principales:	Federico, Marilén, Valverde, Carlos Alfredo, Mattiazzi, Alicia Ramona, Palomeque, Julieta
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2020
Materias:	Medicina sarcoplasmic reticulum Ca2+-ATPase ryanodine receptor 2 arrhythimas phospholamban Apoptosis diabetic myocardiopathy isquemia-reperfusión
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/107960 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6989610&blobtype=pdf https://www.frontiersin.org/articles/10.3389/fphys.2019.01630/full
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Medicina sarcoplasmic reticulum Ca2+-ATPase ryanodine receptor 2 arrhythimas phospholamban Apoptosis diabetic myocardiopathy isquemia-reperfusión
spellingShingle	Medicina sarcoplasmic reticulum Ca2+-ATPase ryanodine receptor 2 arrhythimas phospholamban Apoptosis diabetic myocardiopathy isquemia-reperfusión Federico, Marilén Valverde, Carlos Alfredo Mattiazzi, Alicia Ramona Palomeque, Julieta Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
topic_facet	Medicina sarcoplasmic reticulum Ca2+-ATPase ryanodine receptor 2 arrhythimas phospholamban Apoptosis diabetic myocardiopathy isquemia-reperfusión
description	The present review focusses on the regulation and interplay of cardiac SR Ca<sup>2+</sup> handling proteins involved in SR Ca<sup>2+</sup> uptake and release, i.e., SERCa2/PLN and RyR2. Both RyR2 and SERCA2a/PLN are highly regulated by post-translational modifications and/or different partners’ proteins. These control mechanisms guarantee a precise equilibrium between SR Ca<sup>2+</sup> reuptake and release. The review then discusses how disruption of this balance alters SR Ca<sup>2+</sup> handling and may constitute a first step toward cardiac damage and malignant arrhythmias. In the last part of the review, this concept is exemplified in different cardiac diseases, like prediabetic and diabetic cardiomyopathy, digitalis intoxication and ischemia-reperfusion injury.
format	Articulo Articulo
author	Federico, Marilén Valverde, Carlos Alfredo Mattiazzi, Alicia Ramona Palomeque, Julieta
author_facet	Federico, Marilén Valverde, Carlos Alfredo Mattiazzi, Alicia Ramona Palomeque, Julieta
author_sort	Federico, Marilén
title	Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_short	Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_full	Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_fullStr	Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_full_unstemmed	Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage
title_sort	unbalance between sarcoplasmic reticulum ca<sup>2+</sup> uptake and release: a first step toward ca<sup>2+</sup> triggered arrhythmias and cardiac damage
publishDate	2020
url	http://sedici.unlp.edu.ar/handle/10915/107960 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6989610&blobtype=pdf https://www.frontiersin.org/articles/10.3389/fphys.2019.01630/full
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Unbalance Between Sarcoplasmic Reticulum Ca<sup>2+</sup> Uptake and Release: A First Step Toward Ca<sup>2+</sup> Triggered Arrhythmias and Cardiac Damage

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