Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer

Humanin (HN) is a mitochondrial-derived peptide with cytoprotective efect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor pathogenesis is poor...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Moreno Ayala, Mariela A., Gottardo, María Florencia, Zuccato, Camila Florencia, Pidre, Matías Luis, Nicola Candia, Alejandro Javier, Asad, Antonela Sofia, Imsen, Mercedes, Romanowski, Víctor, Cretón, Aldo, Isla Larrain, Marina Teresita, Seilicovich, Adriana, Candolfi, Marianela
Formato: Articulo
Lenguaje:Español
Publicado: 2020
Materias:
Ciencias Médicas
Ciencias Exactas
Humanin
Tumor progression
Breast cancer
Immunohistochemistry
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107851
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7244539&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107851
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
Ciencias Exactas
Humanin
Tumor progression
Breast cancer
Immunohistochemistry
spellingShingle Ciencias Médicas
Ciencias Exactas
Humanin
Tumor progression
Breast cancer
Immunohistochemistry
Moreno Ayala, Mariela A.
Gottardo, María Florencia
Zuccato, Camila Florencia
Pidre, Matías Luis
Nicola Candia, Alejandro Javier
Asad, Antonela Sofia
Imsen, Mercedes
Romanowski, Víctor
Cretón, Aldo
Isla Larrain, Marina Teresita
Seilicovich, Adriana
Candolfi, Marianela
Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
topic_facet Ciencias Médicas
Ciencias Exactas
Humanin
Tumor progression
Breast cancer
Immunohistochemistry
description Humanin (HN) is a mitochondrial-derived peptide with cytoprotective efect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from chemotherapy, its role in tumor pathogenesis is poorly understood. Here, we evaluated the efect of HN on the progression of experimental triple negative breast cancer (TNBC). The meta-analysis of transcriptomic data from The Cancer Genome Atlas indicated that HN and its receptors are expressed in breast cancer specimens. By immunohistochemistry we observed up-regulation of HN in TNBC biopsies when compared to mammary gland sections from healthy donors. Addition of exogenous HN protected TNBC cells from apoptotic stimuli whereas shRNA-mediated HN silencing reduced their viability and enhanced their chemo-sensitivity. Systemic administration of HN in TNBC-bearing mice reduced tumor apoptotic rate, impaired the antitumor and anti-metastatic efect of chemotherapy and stimulated tumor progression, accelerating tumor growth and development of spontaneous lung metastases. These fndings suggest that HN may exert pro-tumoral efects and thus, caution should be taken when using exogenous HN to treat degenerative diseases. In addition, our study suggests that HN blockade could constitute a therapeutic strategy to improve the efcacy of chemotherapy in breast cancer.
format Articulo
Articulo
author Moreno Ayala, Mariela A.
Gottardo, María Florencia
Zuccato, Camila Florencia
Pidre, Matías Luis
Nicola Candia, Alejandro Javier
Asad, Antonela Sofia
Imsen, Mercedes
Romanowski, Víctor
Cretón, Aldo
Isla Larrain, Marina Teresita
Seilicovich, Adriana
Candolfi, Marianela
author_facet Moreno Ayala, Mariela A.
Gottardo, María Florencia
Zuccato, Camila Florencia
Pidre, Matías Luis
Nicola Candia, Alejandro Javier
Asad, Antonela Sofia
Imsen, Mercedes
Romanowski, Víctor
Cretón, Aldo
Isla Larrain, Marina Teresita
Seilicovich, Adriana
Candolfi, Marianela
author_sort Moreno Ayala, Mariela A.
title Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
title_short Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
title_full Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
title_fullStr Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
title_full_unstemmed Humanin Promotes Tumor Progression in Experimental Triple Negative Breast Cancer
title_sort humanin promotes tumor progression in experimental triple negative breast cancer
publishDate 2020
url http://sedici.unlp.edu.ar/handle/10915/107851
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7244539&blobtype=pdf
work_keys_str_mv AT morenoayalamarielaa humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT gottardomariaflorencia humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT zuccatocamilaflorencia humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT pidrematiasluis humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT nicolacandiaalejandrojavier humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT asadantonelasofia humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT imsenmercedes humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT romanowskivictor humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT cretonaldo humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT islalarrainmarinateresita humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT seilicovichadriana humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
AT candolfimarianela humaninpromotestumorprogressioninexperimentaltriplenegativebreastcancer
bdutipo_str Repositorios
_version_ 1764820443701706752

Ejemplares similares