<i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy

Mitosis has been traditionally considered a metabolically inactive phase. We have previously shown, however, that extensive alterations in lipids occur as the cells traverse mitosis, including increased <i>de novo</i> fatty acid (FA) and phosphatidylcholine (PtdCho) synthesis and decreas...

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Detalles Bibliográficos
Autores principales: Rodriguez Sawicki, Luciana, García, Karina Andrea, Córsico, Betina, Scaglia, Natalia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Medicina
fatty acid
phospholipid
cell cycle
nuclear envelope
FASN
cancer
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107827
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6619966&blobtype=pdf
https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1629792
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107827
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
fatty acid
phospholipid
cell cycle
nuclear envelope
FASN
cancer
spellingShingle Medicina
fatty acid
phospholipid
cell cycle
nuclear envelope
FASN
cancer
Rodriguez Sawicki, Luciana
García, Karina Andrea
Córsico, Betina
Scaglia, Natalia
<i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
topic_facet Medicina
fatty acid
phospholipid
cell cycle
nuclear envelope
FASN
cancer
description Mitosis has been traditionally considered a metabolically inactive phase. We have previously shown, however, that extensive alterations in lipids occur as the cells traverse mitosis, including increased <i>de novo</i> fatty acid (FA) and phosphatidylcholine (PtdCho) synthesis and decreased lysophospholipid content. Given the diverse structural and functional properties of these lipids, we sought to study their metabolic fate and their importance for cell cycle completion. Here we show that FA and PtdCho synthesized at the mitotic exit are destined to the nuclear envelope. Importantly, FA and PtdCho synthesis, but not the decrease in lysophospholipid content, are necessary for cell cycle completion beyond G<sub>2</sub>/M. Moreover, the presence of alternative pathways for PtdCho synthesis renders the cells less sensitive to its inhibition than to the impairment of FA synthesis. FA synthesis, thus, represents a cell cycle-related metabolic vulnerability that could be exploited for combined chemotherapy. We explored the combination of fatty acid synthase (FASN) inhibition with agents that act at different phases of the cell cycle. Our results show that the effect of FASN inhibition may be enhanced under some drug combinations.
format Articulo
Articulo
author Rodriguez Sawicki, Luciana
García, Karina Andrea
Córsico, Betina
Scaglia, Natalia
author_facet Rodriguez Sawicki, Luciana
García, Karina Andrea
Córsico, Betina
Scaglia, Natalia
author_sort Rodriguez Sawicki, Luciana
title <i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
title_short <i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
title_full <i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
title_fullStr <i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
title_full_unstemmed <i>De novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : Implications for combined chemotherapy
title_sort <i>de novo</i> lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion : implications for combined chemotherapy
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/107827
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6619966&blobtype=pdf
https://www.tandfonline.com/doi/full/10.1080/15384101.2019.1629792
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bdutipo_str Repositorios
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