The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.

Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human g...

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Detalles Bibliográficos
Autor principal: Bravi, Claudio Marcelo
Formato: Articulo
Lenguaje:Español
Publicado: 2016
Materias:
Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107824
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5161557&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107824
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
spellingShingle Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
Bravi, Claudio Marcelo
The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
topic_facet Ciencias Médicas
Simons Genome Diversity Project
Human genome variation
Divergence
description Here we report the Simons Genome Diversity Project data set: high quality genomes from 300 individuals from 142 diverse populations. These genomes include at least 5.8 million base pairs that are not present in the human reference genome. Our analysis reveals key features of the landscape of human genome variation, including that the rate of accumulation of mutations has accelerated by about 5% in non-Africans compared to Africans since divergence. We show that the ancestors of some pairs of present-day human populations were substantially separated by 100,000 years ago, well before the archaeologically attested onset of behavioural modernity. We also demonstrate that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans.
format Articulo
Articulo
author Bravi, Claudio Marcelo
author_facet Bravi, Claudio Marcelo
author_sort Bravi, Claudio Marcelo
title The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_short The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_full The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_fullStr The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_full_unstemmed The Simons Genome Diversity Project : 300 genomes from 142 diverse populations.
title_sort simons genome diversity project : 300 genomes from 142 diverse populations.
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/107824
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5161557&blobtype=pdf
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