Role of co-solute in biomolecular stability: glucose, urea and the water structure

We have studied the action of urea and glucose on the stability of DNA and micelles. We measured the melting temperature of aqueous solutions of DNA with urea or glucose as a cosolute; we have also measured the changes in the critical micelle concentrations (cmc) of Sodium Dodecyl Sulfate and Trito...

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Detalles Bibliográficos
Autor principal: Xammar Oro, Juan R. de
Formato: Articulo
Lenguaje:Inglés
Publicado: 2001
Materias:
Biología
Física
DNA
Glucose
Hydrophobic interactions
Micelles
Micellization
Water structure
Urea
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107794
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3456400&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107794
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Física
DNA
Glucose
Hydrophobic interactions
Micelles
Micellization
Water structure
Urea
spellingShingle Biología
Física
DNA
Glucose
Hydrophobic interactions
Micelles
Micellization
Water structure
Urea
Xammar Oro, Juan R. de
Role of co-solute in biomolecular stability: glucose, urea and the water structure
topic_facet Biología
Física
DNA
Glucose
Hydrophobic interactions
Micelles
Micellization
Water structure
Urea
description We have studied the action of urea and glucose on the stability of DNA and micelles. We measured the melting temperature of aqueous solutions of DNA with urea or glucose as a cosolute; we have also measured the changes in the critical micelle concentrations (cmc) of Sodium Dodecyl Sulfate and Triton X-100 by addition of urea and glucose. Our experimental results show that glucose increases the melting temperature of DNA and decreases the cmc, while urea acts in the contrary direction. The effects of urea and glucose on the stability of DNA and micelles can be explained by the weakening and enhancement of hydrophobic interactions, respectively. These effects on hydrophobic interactions are discussed in this paper.
format Articulo
Articulo
author Xammar Oro, Juan R. de
author_facet Xammar Oro, Juan R. de
author_sort Xammar Oro, Juan R. de
title Role of co-solute in biomolecular stability: glucose, urea and the water structure
title_short Role of co-solute in biomolecular stability: glucose, urea and the water structure
title_full Role of co-solute in biomolecular stability: glucose, urea and the water structure
title_fullStr Role of co-solute in biomolecular stability: glucose, urea and the water structure
title_full_unstemmed Role of co-solute in biomolecular stability: glucose, urea and the water structure
title_sort role of co-solute in biomolecular stability: glucose, urea and the water structure
publishDate 2001
url http://sedici.unlp.edu.ar/handle/10915/107794
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3456400&blobtype=pdf
work_keys_str_mv AT xammarorojuanrde roleofcosoluteinbiomolecularstabilityglucoseureaandthewaterstructure
bdutipo_str Repositorios
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