Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine

In our recent publication p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine” (1) we showed by a combination of experimental and simulation techniques that the peptide p31-43 Gliadin has an intrinsic propensity to form oligome...

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Detalles Bibliográficos
Autores principales: Barrera, Exequiel, Chirdo, Fernando Gabriel, Pantano, Sergio
Formato: Articulo Comunicacion
Lenguaje:Inglés
Publicado: 2019
Materias:
Biología
p31-43
Peptides
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107791
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6895017&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107791
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
p31-43
Peptides
spellingShingle Biología
p31-43
Peptides
Barrera, Exequiel
Chirdo, Fernando Gabriel
Pantano, Sergio
Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
topic_facet Biología
p31-43
Peptides
description In our recent publication p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine” (1) we showed by a combination of experimental and simulation techniques that the peptide p31-43 Gliadin has an intrinsic propensity to form oligomers, which trigger the NLRP3 inflammasome, resulting in intestinal inflammation and pathology. In particular, molecular simulations performed with the SIRAH force field (2), showed that isolated p31-43 peptides exhibit a broad conformational dynamic with some PPII component, mostly related to the presence of Pro36 and Pro42. Simulation of multiple replicas showed a spontaneous tendency to aggregation with a concomitant increase in the PPII content for Pro38 and Pro 39.
format Articulo
Comunicacion
author Barrera, Exequiel
Chirdo, Fernando Gabriel
Pantano, Sergio
author_facet Barrera, Exequiel
Chirdo, Fernando Gabriel
Pantano, Sergio
author_sort Barrera, Exequiel
title Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
title_short Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
title_full Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
title_fullStr Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
title_full_unstemmed Commentary: p31-43 Gliadin Peptide Forms Oligomers and Induces NLRP3 Inflammasome/Caspase 1- Dependent Mucosal Damage in Small Intestine
title_sort commentary: p31-43 gliadin peptide forms oligomers and induces nlrp3 inflammasome/caspase 1- dependent mucosal damage in small intestine
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/107791
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6895017&blobtype=pdf
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