Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling

The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promo...

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Detalles Bibliográficos
Autores principales: Aiello, Ernesto Alejandro, De Giusti, Verónica Celeste
Formato: Articulo
Lenguaje:Español
Publicado: 2013
Materias:
Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107781
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3584305&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107781
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
spellingShingle Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
Aiello, Ernesto Alejandro
De Giusti, Verónica Celeste
Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
topic_facet Ciencias Médicas
Angiotensin II
Calcium overload
Cardiac arrhythmias
Cardiac hypertrophy
Electrogenic sodium/bicarbonate cotransporter
Sodium overload
description The sodium/bicarbonate cotransporter (NBC) is, with the Na<sup>+</sup> /H<sup>+</sup> exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pH<sub>i</sub>). In the heart exists at least three isoforms of NBC, one that promotes the co-influx of 1 molecule of Na<sup>+</sup> per 1molecule of HCO<sub>3</sub><sup>-</sup> (electroneutral isoform; nNBC) and two others that generates the co-influx of 1 molecule of Na<sup>+</sup> per 2 molecules of HCO<sub>3</sub><sup>-</sup> (electrogenic isoforms; eNBC). In addition, the eNBC generates an anionic repolarizing current that modulate the cardiac action potential (CAP), adding to such isoforms the relevance to modulate the electrophysiological function of the heart. Angiotensin II (Ang II) is one of the main hormones that regulate cardiac physiology. The alkalinizing mechanisms (NHE and NBC) are stimulated by Ang II, increasing pH<sub>i</sub> and intracellular Na<sup>+</sup> concentration, which indirectly, due to the stimulation of the Na<sup>+</sup>/Ca<sup>2+</sup> exchanger (NCX) operating in the reverse form, leads to an increase in the intracellular Ca<sup>2+</sup> concentration. Interestingly, it has been shown that Ang II exhibits an opposite effect on NBC isoforms: it activates the nNBC and inhibits the eNBC. This inhibition generates a CAP prolongation, which could directly increase the intracellular Ca<sup>2+</sup> concentration. The regulation of the intracellular Na<sup>+</sup> and Ca<sup>2+</sup> concentrations is crucial for the cardiac cellular physiology, but these ions are also involved in the development of cardiac hypertrophy and the damage produced by ischemia-reperfusion, suggesting a potential role of NBC in cardiac diseases.
format Articulo
Articulo
author Aiello, Ernesto Alejandro
De Giusti, Verónica Celeste
author_facet Aiello, Ernesto Alejandro
De Giusti, Verónica Celeste
author_sort Aiello, Ernesto Alejandro
title Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_short Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_full Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_fullStr Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_full_unstemmed Regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin II : Potential Contribution to structural, ionic and electrophysiological myocardial remodelling
title_sort regulation of the cardiac sodium/bicarbonate cotransporter by angiotensin ii : potential contribution to structural, ionic and electrophysiological myocardial remodelling
publishDate 2013
url http://sedici.unlp.edu.ar/handle/10915/107781
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3584305&blobtype=pdf
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