Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model
Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI). Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volu...
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Formato: | Articulo |
Lenguaje: | Inglés |
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2020
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Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107778 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf |
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I19-R120-10915-107778 |
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Universidad Nacional de La Plata |
institution_str |
I-19 |
repository_str |
R-120 |
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SEDICI (UNLP) |
language |
Inglés |
topic |
Ciencias Médicas Adalimumab/administration & dosage Respiration, artificial Respiratory failure Ventilator-induced lung injury |
spellingShingle |
Ciencias Médicas Adalimumab/administration & dosage Respiration, artificial Respiratory failure Ventilator-induced lung injury Correger, Enrique Marcos, Josefina Laguens, Graciela Stringa, Pablo Luis Cardinal Fernández, Pablo Blanch, Lluis Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
topic_facet |
Ciencias Médicas Adalimumab/administration & dosage Respiration, artificial Respiratory failure Ventilator-induced lung injury |
description |
Objective: To determine whether adalimumab administration before mechanical ventilation reduces ventilator- -induced lung injury (VILI).
Methods: Eighteen rats randomized into 3 groups underwent mechanical ventilation for 3 hours with a fraction of inspired oxygen = 0.40% including a low tidal volume group (n = 6), where tidal volume = 8mL/kg and positive end-expiratory pressure = 5cmH2O; a high tidal volume group (n = 6), where tidal volume = 35mL/kg and positive end-expiratory pressure = 0; and a pretreated + high tidal volume group (n = 6) where adalimumab (100ug/kg) was administered intraperitoneally 24 hours before mechanical ventilation + tidal volume = 35mL/ kg and positive end-expiratory pressure = 0. ANOVA was used to compare histological damage (ATS 2010 Lung Injury Scoring System), pulmonary edema, lung compliance, arterial partial pressure of oxygen, and mean arterial pressure among the groups.
Results: After 3 hours of ventilation, the mean histological lung injury score was higher in the high tidal volume group than in the low tidal volume group (0.030 versus 0.0051, respectively, p = 0.003). The high tidal volume group showed diminished lung compliance at 3 hours (p = 0.04) and hypoxemia (p = 0,018 versus control). Pretreated HVt group had an improved histological score, mainly due to a significant reduction in leukocyte infiltration (p = 0.003).
Conclusion: Histological examination after 3 hours of injurious ventilation revealed ventilator-induced lung injury in the absence of measurable changes in lung mechanics or oxygenation; administering adalimumab before mechanical ventilation reduced lung edema and histological damage. |
format |
Articulo Articulo |
author |
Correger, Enrique Marcos, Josefina Laguens, Graciela Stringa, Pablo Luis Cardinal Fernández, Pablo Blanch, Lluis |
author_facet |
Correger, Enrique Marcos, Josefina Laguens, Graciela Stringa, Pablo Luis Cardinal Fernández, Pablo Blanch, Lluis |
author_sort |
Correger, Enrique |
title |
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
title_short |
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
title_full |
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
title_fullStr |
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
title_full_unstemmed |
Pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
title_sort |
pretreatment with adalimumab reduces ventilator-induced lung injury in an experimental model |
publishDate |
2020 |
url |
http://sedici.unlp.edu.ar/handle/10915/107778 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7206963&blobtype=pdf |
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Repositorios |
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