Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia

Glucocorticoid receptor-like immunoreactivity (GCRI) was found in the normal pituitary pars intermedia (PI) when immunohistochemistry was used. Since in previous studies we described two kinds of cells in the denervated (grafted) PI, i.e., "light cells" (overactive cells which do not conta...

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Autores principales: Iturriza, Fermín C., Gómez Dumm, César Leandro Alberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 1992
Materias:
Ciencias Médicas
Pituitary gland
Pars intermedia
Transplants
Immunohistochemistry
Glucocorticoid receptors
Dopamine
Melanocyte-stimulating hormone
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107746
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2565136&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107746
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Pituitary gland
Pars intermedia
Transplants
Immunohistochemistry
Glucocorticoid receptors
Dopamine
Melanocyte-stimulating hormone
spellingShingle Ciencias Médicas
Pituitary gland
Pars intermedia
Transplants
Immunohistochemistry
Glucocorticoid receptors
Dopamine
Melanocyte-stimulating hormone
Iturriza, Fermín C.
Gómez Dumm, César Leandro Alberto
Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
topic_facet Ciencias Médicas
Pituitary gland
Pars intermedia
Transplants
Immunohistochemistry
Glucocorticoid receptors
Dopamine
Melanocyte-stimulating hormone
description Glucocorticoid receptor-like immunoreactivity (GCRI) was found in the normal pituitary pars intermedia (PI) when immunohistochemistry was used. Since in previous studies we described two kinds of cells in the denervated (grafted) PI, i.e., "light cells" (overactive cells which do not contain detectable melanocytestimulating hormone) and "dark cells" (hypoactive cells which contain the hormone), it was decided to investigate whether different patterns of distribution of the receptors could be detected in the glared gland when compared with the intact PI. Intact glands showed the receptors located in the nucleus. In transplanted glands, it was observed that light cells showed receptors in both the nuclei and the cytoplasm; on the other hand, dark cells displayed them in the nuclei only, as is the case in all cells of the normal PI. We had previously interpreted dark cells as dopamine-indifferent whereas light cells were considered dopamine-sensitive. The changes in the distribution of GCR after denervation by grafting, which only affected the light cells, support the view of other authors that GCR of the pars intermedia are under the influence of dopamine and reinforce our opinion that dark cells are dopamine-indifferent.
format Articulo
Articulo
author Iturriza, Fermín C.
Gómez Dumm, César Leandro Alberto
author_facet Iturriza, Fermín C.
Gómez Dumm, César Leandro Alberto
author_sort Iturriza, Fermín C.
title Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
title_short Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
title_full Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
title_fullStr Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
title_full_unstemmed Cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
title_sort cytological differences in the localization of glucocorticoid receptor-like immunoreactivity in the normal and transplanted pituitary pars intermedia
publishDate 1992
url http://sedici.unlp.edu.ar/handle/10915/107746
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2565136&blobtype=pdf
work_keys_str_mv AT iturrizaferminc cytologicaldifferencesinthelocalizationofglucocorticoidreceptorlikeimmunoreactivityinthenormalandtransplantedpituitaryparsintermedia
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bdutipo_str Repositorios
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