The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata
Peptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were hi...
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| Autores principales: | , , , |
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| Formato: | Articulo |
| Lenguaje: | Español |
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2019
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107737 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6629687&blobtype=pdf |
| Aporte de: |
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I19-R120-10915-107737 |
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dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Español |
| topic |
Ciencias Naturales Intercellular messengers Allatotropin/Orexin GPCR family |
| spellingShingle |
Ciencias Naturales Intercellular messengers Allatotropin/Orexin GPCR family Alzugaray, María Eugenia Bruno, María Cecilia Villalobos Sambucaro, María José Ronderos, Jorge Rafael The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| topic_facet |
Ciencias Naturales Intercellular messengers Allatotropin/Orexin GPCR family |
| description |
Peptidic messengers constitute a highly diversifed group of intercellular messengers widely distributed in nature that regulate a great number of physiological processes in Metazoa. Being crucial for life, it seem that they have appeared in the ancestral group from which Metazoa evolved, and were highly conserved along the evolutionary process. Peptides act mainly through G-protein coupled receptors (GPCRs), a family of transmembrane molecules. GPCRs are also widely distributed in nature being present in metazoan, but also in Choanofagellata and Fungi. Among GPCRs, the Allatotropin/Orexin (AT/Ox) family is particularly characterized by the presence of the DRW motif in the second intracellular loop (IC Loop 2), and seems to be present in Cnidaria, Placozoa and in Bilateria, suggesting that it was present in the common ancestor of Metazoa. Looking for the evolutionary history of this GPCRs we searched for corresponding sequences in public databases. Our results suggest that AT/Ox receptors were highly conserved along evolutionary process, and that they are characterized by the presence of the E/DRWYAI motif at the IC Loop 2. Phylogenetic analyses show that AT/Ox family of receptors refects evolutionary relationships that agree with current phylogenetic understanding in Actinopterygii and Sauropsida, including also the largely discussed position of Testudines. |
| format |
Articulo Articulo |
| author |
Alzugaray, María Eugenia Bruno, María Cecilia Villalobos Sambucaro, María José Ronderos, Jorge Rafael |
| author_facet |
Alzugaray, María Eugenia Bruno, María Cecilia Villalobos Sambucaro, María José Ronderos, Jorge Rafael |
| author_sort |
Alzugaray, María Eugenia |
| title |
The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| title_short |
The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| title_full |
The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| title_fullStr |
The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| title_full_unstemmed |
The Evolutionary History of The Orexin/Allatotropin GPCR Family : From Placozoa and Cnidaria to Vertebrata |
| title_sort |
evolutionary history of the orexin/allatotropin gpcr family : from placozoa and cnidaria to vertebrata |
| publishDate |
2019 |
| url |
http://sedici.unlp.edu.ar/handle/10915/107737 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6629687&blobtype=pdf |
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