Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithel...

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Autores principales: Zanuzzi, Carolina Natalia, Nishida, Fabián, Portiansky, Enrique Leo, Fontana, Paula Andrea, Gimeno, Eduardo Juan, Barbeito, Claudio Gustavo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2012
Materias:
Ciencias Veterinarias
1,25-Dihydroxyvitamin D3
Intestine
Rabbit
Proliferation
Apoptosis
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107721
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7125838&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107721
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
1,25-Dihydroxyvitamin D3
Intestine
Rabbit
Proliferation
Apoptosis
spellingShingle Ciencias Veterinarias
1,25-Dihydroxyvitamin D3
Intestine
Rabbit
Proliferation
Apoptosis
Zanuzzi, Carolina Natalia
Nishida, Fabián
Portiansky, Enrique Leo
Fontana, Paula Andrea
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
topic_facet Ciencias Veterinarias
1,25-Dihydroxyvitamin D3
Intestine
Rabbit
Proliferation
Apoptosis
description Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant <i>Solanum glaucophyllum</i>. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by <i>S. glaucophyllum</i> is discussed.
format Articulo
Articulo
author Zanuzzi, Carolina Natalia
Nishida, Fabián
Portiansky, Enrique Leo
Fontana, Paula Andrea
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_facet Zanuzzi, Carolina Natalia
Nishida, Fabián
Portiansky, Enrique Leo
Fontana, Paula Andrea
Gimeno, Eduardo Juan
Barbeito, Claudio Gustavo
author_sort Zanuzzi, Carolina Natalia
title Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
title_short Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
title_full Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
title_fullStr Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
title_full_unstemmed Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
title_sort effects of solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits
publishDate 2012
url http://sedici.unlp.edu.ar/handle/10915/107721
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC7125838&blobtype=pdf
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