Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi

Entomopathogenic fungi are the only insect pathogens able to infect their host by adhesion to the surface and penetration through the cuticle. Although the possibility of fungal infection per os was described almost a century ago, there is an information gap of several decades regarding this topic,...

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Autores principales:	Mannino, María Constanza, Huarte Bonnet, Carla, Davyt Colo, Belén, Pedrini, Nicolás
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2019
Materias:	Química Ciencias Médicas Beauveria bassiana Metarhizium spp Oral infection Per os entry Bacterial-like toxins
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/107713 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6616882&blobtype=pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-107713
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institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Química Ciencias Médicas Beauveria bassiana Metarhizium spp Oral infection Per os entry Bacterial-like toxins
spellingShingle	Química Ciencias Médicas Beauveria bassiana Metarhizium spp Oral infection Per os entry Bacterial-like toxins Mannino, María Constanza Huarte Bonnet, Carla Davyt Colo, Belén Pedrini, Nicolás Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
topic_facet	Química Ciencias Médicas Beauveria bassiana Metarhizium spp Oral infection Per os entry Bacterial-like toxins
description	Entomopathogenic fungi are the only insect pathogens able to infect their host by adhesion to the surface and penetration through the cuticle. Although the possibility of fungal infection per os was described almost a century ago, there is an information gap of several decades regarding this topic, which was poorly explored due to the continuous elucidation of cuticular infection processes that lead to insect death by mycosis. Recently, with the advent of next-generation sequencing technologies, the genomes of the main entomopathogenic fungi became available, and many fungal genes potentially useful for oral infection were described. Among the entomopathogenic Hypocreales that have been sequenced, <i>Beauveria bassiana</i> (Balsamo-Crivelli) Vuillemin (Cordycipitaceae) is the main candidate to explore this pathway since it has a major number of shared genes with other non-fungal pathogens that infect orally, such as <i>Bacillus thuringiensis</i> Berliner (Bacillales: Bacillaceae). This finding gives B. bassiana a potential advantage over other entomopathogenic fungi: the possibility to infect through both routes, oral and cuticular. In this review, we explore all known entry gates for entomopathogenic fungi, with emphasis on the infection per os. We also set out the fungal infection process in a more integral approach, as a need to exploit its full potential for insect control, considering all of its virulence factors and the conditions needed to improve its virulence against insect that might offer some resistance to the common infection through the cuticle.
format	Articulo Articulo
author	Mannino, María Constanza Huarte Bonnet, Carla Davyt Colo, Belén Pedrini, Nicolás
author_facet	Mannino, María Constanza Huarte Bonnet, Carla Davyt Colo, Belén Pedrini, Nicolás
author_sort	Mannino, María Constanza
title	Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
title_short	Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
title_full	Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
title_fullStr	Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
title_full_unstemmed	Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi
title_sort	is the insect cuticle the only entry gate for fungal infection? : insights into alternative modes of action of entomopathogenic fungi
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/107713 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6616882&blobtype=pdf
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bdutipo_str	Repositorios
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Is the Insect Cuticle the only Entry Gate for Fungal Infection? : Insights into Alternative Modes of Action of Entomopathogenic Fungi

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