Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response
Reinfection of chronic chagasic mice after treatment with nifurtimox resulted in different outcomes according to the number of parasites used for inoculation. Nifurtimox-treated chagasic animals injected with 2,500 trypomastigotes developed higher parasitemia and increased mortality compared with no...
Guardado en:
| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
1988
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107710 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC172142&blobtype=pdf |
| Aporte de: |
| id |
I19-R120-10915-107710 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Mice Trypomastigotes Immune response |
| spellingShingle |
Ciencias Médicas Mice Trypomastigotes Immune response Cabeza Meckert, P. Chambó, Jorge Laguens, R. P. Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| topic_facet |
Ciencias Médicas Mice Trypomastigotes Immune response |
| description |
Reinfection of chronic chagasic mice after treatment with nifurtimox resulted in different outcomes according to the number of parasites used for inoculation. Nifurtimox-treated chagasic animals injected with 2,500 trypomastigotes developed higher parasitemia and increased mortality compared with nontreated chagasic mice. When reinfection was done with 25 trypomastigotes, treated and nontreated animals showed similar parasitemias and mortalities, which were significantly higher in nonchagasic controls infected for the first time. Immunological studies showed that treatment with nifurtimox led to a decrease in anti-<i>Trypanosoma cruzi</i> antibodies engaged in parasite destruction, inducing either complement-dependent lysis or antibodydependent cytotoxicity, but no difference in anti-<i>T. cruzi</i> cell-mediated immunity was found between treated and nontreated chagasic animals. It is concluded that treatment with nifurtimox leads to a loss of resistance to reinfection with a large number of trypanosomes, which is maintained with challenge with a few parasites, and that these two thresholds of premunition are probably associated with humoral and cell-mediated anti-<i>T. cruzi</i> immune responses, respectively. |
| format |
Articulo Articulo |
| author |
Cabeza Meckert, P. Chambó, Jorge Laguens, R. P. |
| author_facet |
Cabeza Meckert, P. Chambó, Jorge Laguens, R. P. |
| author_sort |
Cabeza Meckert, P. |
| title |
Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| title_short |
Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| title_full |
Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| title_fullStr |
Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| title_full_unstemmed |
Differences in resistance to reinfection with low and high inocula of <i>Trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| title_sort |
differences in resistance to reinfection with low and high inocula of <i>trypanosoma cruzi</i> in chagasic mice treated with nifurtimox and relation to immune response |
| publishDate |
1988 |
| url |
http://sedici.unlp.edu.ar/handle/10915/107710 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC172142&blobtype=pdf |
| work_keys_str_mv |
AT cabezameckertp differencesinresistancetoreinfectionwithlowandhighinoculaofitrypanosomacruziiinchagasicmicetreatedwithnifurtimoxandrelationtoimmuneresponse AT chambojorge differencesinresistancetoreinfectionwithlowandhighinoculaofitrypanosomacruziiinchagasicmicetreatedwithnifurtimoxandrelationtoimmuneresponse AT laguensrp differencesinresistancetoreinfectionwithlowandhighinoculaofitrypanosomacruziiinchagasicmicetreatedwithnifurtimoxandrelationtoimmuneresponse |
| bdutipo_str |
Repositorios |
| _version_ |
1764820443533934596 |