Is the protection against ischemia induced by red wine linked to its antioxidant capacity?
Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury. Animals and methods: The antioxidant properties of three RWE were determined using different free radic...
| Autores principales: | , , , |
|---|---|
| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2001
|
| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107697 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2858997&blobtype=pdf |
| Aporte de: |
| id |
I19-R120-10915-107697 |
|---|---|
| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Ciencias Médicas Antioxidant capacity Ischemia Red wine Reperfusion |
| spellingShingle |
Ciencias Médicas Antioxidant capacity Ischemia Red wine Reperfusion Mosca, Susana María Schinella, Guillermo Raúl Tournier, Horacio Alfio Cingolani, Horacio Eugenio Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| topic_facet |
Ciencias Médicas Antioxidant capacity Ischemia Red wine Reperfusion |
| description |
Objective: To establish whether the total antioxidant capacity of nonalcoholic extracts of three Argentine red wines (RWE) is correlated with their protection against ischemia-reperfusion injury.
Animals and methods: The antioxidant properties of three RWE were determined using different free radicalgenerating systems. To examine the effects of these RWE during a 20 min global ischemic period followed by 30 min of reperfusion, isolated rat hearts received 50 µg/mL of RWE 1 (cabernetsauvignon), RWE 2 (malbec) or RWE 3 (a commercial mixture of cabernet-sauvignon, malbec and merlot) 10 min before and after ischemia. Left ventricular developed pressure (LVDP), maximal velocity of rise of left ventricular pressure (+dP/dtmax) and left ventricular end-diastolic pressure (LVEDP) were used to assess contractility and diastolic function.
Results: All RWE inhibited lipid peroxidation induced by the Cl4C/NADPH system in a similar proportion (42±4%, 47±9% and 43±14% for RWE 1, RWE 2 and RWE 3, respectively). The scavenging activity of superoxide anion and 2,2-diphenyl-1-picrylhydrazyl radical was about the same with the three RWE. In hearts without RWE treatment, LVDP and +dP/dtmax were 61±4% and 62±5%, respectively, at the end of the reperfusion period. Infusion of RWE 1 and RWE 2 significantly improved postischemic recovery (LVDP and +dP/dtmax were 102±4% and 101±4% for RWE 1 and 92±5% and 91±5% for RWE 2, respectively) and attenuated the increase of LVEDP. RWE 3 did not improve either systolic or diastolic dysfunction.
Conclusion: These data show that although the three nonalcoholic RWE exhibit a similar total antioxidant capacity, only two of them protect the heart against myocardial stunning, suggesting that the protective effect is not primarily linked to the antioxidant properties of the extracts. |
| format |
Articulo Articulo |
| author |
Mosca, Susana María Schinella, Guillermo Raúl Tournier, Horacio Alfio Cingolani, Horacio Eugenio |
| author_facet |
Mosca, Susana María Schinella, Guillermo Raúl Tournier, Horacio Alfio Cingolani, Horacio Eugenio |
| author_sort |
Mosca, Susana María |
| title |
Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| title_short |
Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| title_full |
Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| title_fullStr |
Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| title_full_unstemmed |
Is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| title_sort |
is the protection against ischemia induced by red wine linked to its antioxidant capacity? |
| publishDate |
2001 |
| url |
http://sedici.unlp.edu.ar/handle/10915/107697 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2858997&blobtype=pdf |
| work_keys_str_mv |
AT moscasusanamaria istheprotectionagainstischemiainducedbyredwinelinkedtoitsantioxidantcapacity AT schinellaguillermoraul istheprotectionagainstischemiainducedbyredwinelinkedtoitsantioxidantcapacity AT tournierhoracioalfio istheprotectionagainstischemiainducedbyredwinelinkedtoitsantioxidantcapacity AT cingolanihoracioeugenio istheprotectionagainstischemiainducedbyredwinelinkedtoitsantioxidantcapacity |
| bdutipo_str |
Repositorios |
| _version_ |
1764820443521351682 |