Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation

The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the...

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Detalles Bibliográficos
Autores principales:	Curciarello, Renata, Canziani, Karina Eva, Docena, Guillermo Horacio, Muglia, Cecilia Isabel
Formato:	Articulo
Lenguaje:	Inglés
Publicado:	2019
Materias:	Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/107685 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6467945&blobtype=pdf https://www.frontiersin.org/articles/10.3389/fimmu.2019.00647/full
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-107685
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota
spellingShingle	Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota Curciarello, Renata Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
topic_facet	Ciencias Exactas Biología gut inflammation inflammatory bowel disease intestinal epithelial cells intestinal fibroblasts immune cell activation/modulation intestinal microbiota
description	The mucosal immune system constitutes a physical and dynamic barrier against foreign antigens and pathogens and exerts control mechanisms to maintain intestinal tolerance to the microbiota and food antigens. Chronic alterations of the intestinal homeostasis predispose to inflammatory diseases of the gastrointestinal tract, such as Inflammatory Bowel Diseases (IBD). There is growing evidence that the frequency and severity of these diseases are increasing worldwide, which may be probably due to changes in environmental factors. Several stromal and immune cells are involved in this delicate equilibrium that dictates homeostasis. In this review we aimed to summarize the role of epithelial cells and fibroblasts in the induction of mucosal inflammation in the context of IBD. It has been extensively described that environmental factors are key players in this process, and the microbiome of the gastrointestinal tract is currently being intensively investigated due to its profound impact the immune response. Recent findings have demonstrated the interplay between dietary and environmental components, the gut microbiome, and immune cells. “Western” dietary patterns, such as high caloric diets, and pollution can induce alterations in the gut microbiome that in turn affect the intestinal and systemic homeostasis. Here we summarize current knowledge on the influence of dietary components and air particulate matters on gut microbiome composition, and the impact on stromal and immune cells, with a particular focus on promoting local inflammation.
format	Articulo Articulo
author	Curciarello, Renata Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel
author_facet	Curciarello, Renata Canziani, Karina Eva Docena, Guillermo Horacio Muglia, Cecilia Isabel
author_sort	Curciarello, Renata
title	Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_short	Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_full	Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_fullStr	Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_full_unstemmed	Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation
title_sort	contribution of non-immune cells to activation and modulation of the intestinal inflammation
publishDate	2019
url	http://sedici.unlp.edu.ar/handle/10915/107685 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6467945&blobtype=pdf https://www.frontiersin.org/articles/10.3389/fimmu.2019.00647/full
work_keys_str_mv	AT curciarellorenata contributionofnonimmunecellstoactivationandmodulationoftheintestinalinflammation AT canzianikarinaeva contributionofnonimmunecellstoactivationandmodulationoftheintestinalinflammation AT docenaguillermohoracio contributionofnonimmunecellstoactivationandmodulationoftheintestinalinflammation AT mugliaceciliaisabel contributionofnonimmunecellstoactivationandmodulationoftheintestinalinflammation
bdutipo_str	Repositorios
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Contribution of Non-immune Cells to Activation and Modulation of the Intestinal Inflammation

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