Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction

Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also pr...

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Detalles Bibliográficos
Autores principales: Martín, Pedro, Rebolledo, Alejandro, Roldán Palomo, Ana Rocío, Moncada, Melisa, Piccinini, Luciano, Milesi, María Verónica
Formato: Articulo Revision
Lenguaje:Inglés
Publicado: 2014
Materias:
Biología
Human umbilical artery
K+ channels
Patch-clamp
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107645
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107645
record_format dspace
spelling I19-R120-10915-1076452024-06-14T18:55:33Z http://sedici.unlp.edu.ar/handle/10915/107645 Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction Martín, Pedro Rebolledo, Alejandro Roldán Palomo, Ana Rocío Moncada, Melisa Piccinini, Luciano Milesi, María Verónica 2014 2020-10-23T18:31:23Z en Biología Human umbilical artery K+ channels Patch-clamp Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia. Grupo de Investigación en Fisiología Vascular Articulo Revision http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) application/pdf 432-441
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Human umbilical artery
K+ channels
Patch-clamp
spellingShingle Biología
Human umbilical artery
K+ channels
Patch-clamp
Martín, Pedro
Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
topic_facet Biología
Human umbilical artery
K+ channels
Patch-clamp
description Through their control of cell membrane potential, potassium (K+) channels are among the best known regulators of vascular tone. This article discusses the expression and function of K+ channels in human umbilical artery smooth muscle cells (HUASMCs). We review the bibliographic reports and also present single-channel data recorded in freshly isolated cells. Electrophysiological properties of big conductance, voltage- and Ca2+-sensitive K+ channel and voltage-dependent K+ channels are clearly established in this vessel, where they are involved in contractile state regulation. Their role in the maintenance of membrane potential is an important control mechanism in the determination of the vessel diameter. Additionally, small conductance Ca2+-sensitive K+ channels, 2-pore domains K+ channels and inward rectifier K+ channels also appear to be present in HUASMCs, while intermediate conductance Ca2+-sensitive K+ channels and ATP-sensitive K+ channels could not be identified. In both cases, additional investigation is necessary to reach conclusive evidence of their expression and/or functional role in HUASMCs. Finally, we discuss the role of K+ channels in pregnancy-related pathologies like gestational diabetes and preeclampsia.
format Articulo
Revision
author Martín, Pedro
Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
author_facet Martín, Pedro
Rebolledo, Alejandro
Roldán Palomo, Ana Rocío
Moncada, Melisa
Piccinini, Luciano
Milesi, María Verónica
author_sort Martín, Pedro
title Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_short Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_full Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_fullStr Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_full_unstemmed Diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
title_sort diversity of potassium channels in human umbilical artery smooth muscle cells: a review of their roles in human umbilical artery contraction
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/107645
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