PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment
Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify PDGFRA(+)/SCA-1(+) bone marrow-derived mesenchymal stem cells (Pα(+)S MSCs) as K...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2019
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| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/107504 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6980685&blobtype=pdf |
| Aporte de: |
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I19-R120-10915-107504 |
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| record_format |
dspace |
| institution |
Universidad Nacional de La Plata |
| institution_str |
I-19 |
| repository_str |
R-120 |
| collection |
SEDICI (UNLP) |
| language |
Inglés |
| topic |
Biología Ciencias Médicas Mesenchymal stem cells Gene expression Cancers and neoplasms Carcinogenesis Kaposi sarcoma |
| spellingShingle |
Biología Ciencias Médicas Mesenchymal stem cells Gene expression Cancers and neoplasms Carcinogenesis Kaposi sarcoma Naipauer, Julian Rosario, Santas Gupta, Sachin Premer, Courtney Méndez-Solís, Omayra Schlesinger, Mariana Ponzinibbio, María Virginia Jain, Vaibhav Gay, Lauren Renne, Rolf Chan, Ho Lam Morey, Lluis Salyakina, Daria Abba, Martín Carlos Williams, Sion Hare, Joshua M. Goldschmidt-Clermont, Pascal J. Mesri, Enrique A. PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| topic_facet |
Biología Ciencias Médicas Mesenchymal stem cells Gene expression Cancers and neoplasms Carcinogenesis Kaposi sarcoma |
| description |
Kaposi’s sarcoma (KS) is an AIDS-defining cancer caused by the KS-associated herpesvirus (KSHV). Unanswered questions regarding KS are its cellular ontology and the conditions conducive to viral oncogenesis. We identify PDGFRA(+)/SCA-1(+) bone marrow-derived mesenchymal stem cells (Pα(+)S MSCs) as KS spindle-cell progenitors and found that pro-angiogenic environmental conditions typical of KS are critical for KSHV sarcomagenesis. This is because growth in KS-like conditions generates a de-repressed KSHV epigenome allowing oncogenic KSHV gene expression in infected Pα(+)S MSCs. Furthermore, these growth conditions allow KSHV-infected Pα(+)S MSCs to overcome KSHV-driven oncogene-induced senescence and cell cycle arrest via a PDGFRA-signaling mechanism; thus identifying PDGFRA not only as a phenotypic determinant for KS-progenitors but also as a critical enabler for viral oncogenesis. |
| format |
Articulo Articulo |
| author |
Naipauer, Julian Rosario, Santas Gupta, Sachin Premer, Courtney Méndez-Solís, Omayra Schlesinger, Mariana Ponzinibbio, María Virginia Jain, Vaibhav Gay, Lauren Renne, Rolf Chan, Ho Lam Morey, Lluis Salyakina, Daria Abba, Martín Carlos Williams, Sion Hare, Joshua M. Goldschmidt-Clermont, Pascal J. Mesri, Enrique A. |
| author_facet |
Naipauer, Julian Rosario, Santas Gupta, Sachin Premer, Courtney Méndez-Solís, Omayra Schlesinger, Mariana Ponzinibbio, María Virginia Jain, Vaibhav Gay, Lauren Renne, Rolf Chan, Ho Lam Morey, Lluis Salyakina, Daria Abba, Martín Carlos Williams, Sion Hare, Joshua M. Goldschmidt-Clermont, Pascal J. Mesri, Enrique A. |
| author_sort |
Naipauer, Julian |
| title |
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| title_short |
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| title_full |
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| title_fullStr |
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| title_full_unstemmed |
PDGFRA defines the mesenchymal stem cell Kaposi's sarcoma progenitors by enabling KSHV oncogenesis in an angiogenic environment |
| title_sort |
pdgfra defines the mesenchymal stem cell kaposi's sarcoma progenitors by enabling kshv oncogenesis in an angiogenic environment |
| publishDate |
2019 |
| url |
http://sedici.unlp.edu.ar/handle/10915/107504 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6980685&blobtype=pdf |
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