Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres

Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CM...

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Detalles Bibliográficos
Autores principales: Bosio, Valeria Elizabeth, Basu, Sreyasree, Abdullha, Fraqooue, Chacón Villalba, María Elizabeth, Güida, Jorge Alberto, Mukherjee, Arup, Castro, Guillermo Raúl
Formato: Articulo
Lenguaje:Inglés
Publicado: 2014
Materias:
Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/107013
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-107013
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
spellingShingle Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
topic_facet Química
Congo Red
Gel microspheres
Guar gum
Alginate
Coacervates
Infrared spectroscopy
description Congo Red (CR) is a hydrophobic dye commonly used for diagnosis and potentially useful as therapeutic agent of beta amyloid plaques in neurodegenerative diseases. CR, as drug model, was encapsulated on Alginate–Carboxy Methyl Guar Gum (Alg–CMGG) blend microspheres. Guar gum 18% carboxymethylated (CMGG) derivative was synthesized in order to improve aqueous solubility, polymer blending and help reduce surface tension. The derivative was confirmed by FTIR spectroscopy, and elemental analysis. Surface tension of the new CMGG is reduced in about 50% compared with the native polymer. Lowering of Guar Gum (GG) aqueous solutions viscosity from 30,000 cps to 350–400 cps in case of CMGG is indicating pseudoplastic fluid behavior modifications. Vibrational spectroscopy analysis confirmed interactions among CR molecules in alginate–CMGG matrices ascribed largely to the aromatic motif of the dye and the biopolymer a polar regions. CR was encapsulated on 68/32% alginate/CMGG blend microspheres as the best formulation tested. The release of CR from the microspheres was not detected at pH = 1.2 in 25 min, but 62% of CR was found in the supernatant when the pH was raised to 7.4 at 37 ºC after 8 h incubation.
format Articulo
Articulo
author Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
author_facet Bosio, Valeria Elizabeth
Basu, Sreyasree
Abdullha, Fraqooue
Chacón Villalba, María Elizabeth
Güida, Jorge Alberto
Mukherjee, Arup
Castro, Guillermo Raúl
author_sort Bosio, Valeria Elizabeth
title Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_short Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_full Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_fullStr Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_full_unstemmed Encapsulation of Congo Red in carboxymethyl guar gum-alginate gel microspheres
title_sort encapsulation of congo red in carboxymethyl guar gum-alginate gel microspheres
publishDate 2014
url http://sedici.unlp.edu.ar/handle/10915/107013
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