Mosquitoes cloak their legs to resist insecticides

Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018....

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Detalles Bibliográficos
Autores principales: Balabanidou, Vasileia, Kefi, Mary, Aivaliotis, Michalis, Koidou, Venetia, Girotti, Juan Roberto, Mijailovsky, Sergio Javier, Juárez, Marta Patricia, Papadogiorgaki, Eva, Chalepakis, George, Kampouraki, Anastasia, Nikolaou, Christoforos, Ranson, Hilary, Vontas, John
Formato: Articulo
Lenguaje:Español
Publicado: 2019
Materias:
Ciencias Médicas
insecticide resistance
cuticle alterations
legs
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/106938
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6661348&blobtype=pdf
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-106938
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Español
topic Ciencias Médicas
insecticide resistance
cuticle alterations
legs
spellingShingle Ciencias Médicas
insecticide resistance
cuticle alterations
legs
Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
Mosquitoes cloak their legs to resist insecticides
topic_facet Ciencias Médicas
insecticide resistance
cuticle alterations
legs
description Malaria incidence has halved since the year 2000, with 80% of the reduction attributable to the use of insecticides. However, insecticide resistance is now widespread, is rapidly increasing in spectrum and intensity across Africa, and may be contributing to the increase of malaria incidence in 2018. The role of detoxification enzymes and target site mutations has been documented in the major malaria vector Anopheles gambiae; however, the emergence of striking resistant phenotypes suggests the occurrence of additional mechanisms. By comparing legs, the most relevant insect tissue for insecticide uptake, we show that resistant mosquitoes largely remodel their leg cuticles via enhanced deposition of cuticular proteins and chitin, corroborating a legthickening phenotype. Moreover, we show that resistant female mosquitoes seal their leg cuticles with higher total and different relative amounts of cuticular hydrocarbons, compared with susceptible ones. The structural and functional alterations in Anopheles female mosquito legs are associated with a reduced uptake of insecticides, substantially contributing to the resistance phenotype.
format Articulo
Articulo
author Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author_facet Balabanidou, Vasileia
Kefi, Mary
Aivaliotis, Michalis
Koidou, Venetia
Girotti, Juan Roberto
Mijailovsky, Sergio Javier
Juárez, Marta Patricia
Papadogiorgaki, Eva
Chalepakis, George
Kampouraki, Anastasia
Nikolaou, Christoforos
Ranson, Hilary
Vontas, John
author_sort Balabanidou, Vasileia
title Mosquitoes cloak their legs to resist insecticides
title_short Mosquitoes cloak their legs to resist insecticides
title_full Mosquitoes cloak their legs to resist insecticides
title_fullStr Mosquitoes cloak their legs to resist insecticides
title_full_unstemmed Mosquitoes cloak their legs to resist insecticides
title_sort mosquitoes cloak their legs to resist insecticides
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/106938
http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6661348&blobtype=pdf
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AT kefimary mosquitoescloaktheirlegstoresistinsecticides
AT aivaliotismichalis mosquitoescloaktheirlegstoresistinsecticides
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AT kampourakianastasia mosquitoescloaktheirlegstoresistinsecticides
AT nikolaouchristoforos mosquitoescloaktheirlegstoresistinsecticides
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AT vontasjohn mosquitoescloaktheirlegstoresistinsecticides
bdutipo_str Repositorios
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