The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation

The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs rapidly, constitutes the well-known Frank-Starling mechanism and it is generally attributed to enhanced myofilament responsiveness to Ca2+. The second phase or slow force response (SFR) occurs gradua...

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Detalles Bibliográficos
Autores principales:	Ennis, Irene Lucía, Aiello, Ernesto Alejandro, Cingolani, Horacio Eugenio, Pérez, Néstor Gustavo
Formato:	Articulo
Lenguaje:	Español
Publicado:	2013
Materias:	Ciencias Médicas Myocardial stretch Slow force response Anrep effect Mineralocorticoid receptor Reactive oxygen species Na+ /H+ exchanger activation
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/106483 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3780348&blobtype=pdf
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-106483
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Español
topic	Ciencias Médicas Myocardial stretch Slow force response Anrep effect Mineralocorticoid receptor Reactive oxygen species Na+ /H+ exchanger activation
spellingShingle	Ciencias Médicas Myocardial stretch Slow force response Anrep effect Mineralocorticoid receptor Reactive oxygen species Na+ /H+ exchanger activation Ennis, Irene Lucía Aiello, Ernesto Alejandro Cingolani, Horacio Eugenio Pérez, Néstor Gustavo The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
topic_facet	Ciencias Médicas Myocardial stretch Slow force response Anrep effect Mineralocorticoid receptor Reactive oxygen species Na+ /H+ exchanger activation
description	The stretch of cardiac muscle increases developed force in two phases. The first phase, which occurs rapidly, constitutes the well-known Frank-Starling mechanism and it is generally attributed to enhanced myofilament responsiveness to Ca2+. The second phase or slow force response (SFR) occurs gradually and is due to an increase in the calcium transient amplitude as a result of a stretch-triggered autocrine/paracrine mechanism. We previously showed that Ca2+ entry through reverse Na+ /Ca2+ exchange underlies the SFR, as the final step of an autocrine/paracrine cascade involving release of angiotensin II/endothelin, and a Na+ /H+ exchanger (NHE-1) activation-mediated rise in Na+ . In the present review we mainly focus on our three latest contributions to the understanding of this signalling pathway triggered by myocardial stretch: 1) The finding that an increased production of reactive oxygen species (ROS) from mitochondrial origin is critical in the activation of the NHE-1 and therefore in the genesis of the SFR; 2) the demonstration of a key role played by the transactivation of the epidermal growth factor receptor; and 3) the involvement of mineralocorticoid receptors (MR) activation in the stretch-triggered cascade leading to the SFR. Among these novel contributions, the critical role played by the MR is perhaps the most important one. This finding may conceivably provide a mechanistic explanation to the recently discovered strikingly beneficial effects of MR antagonism in humans with cardiac hypertrophy and failure.
format	Articulo Articulo
author	Ennis, Irene Lucía Aiello, Ernesto Alejandro Cingolani, Horacio Eugenio Pérez, Néstor Gustavo
author_facet	Ennis, Irene Lucía Aiello, Ernesto Alejandro Cingolani, Horacio Eugenio Pérez, Néstor Gustavo
author_sort	Ennis, Irene Lucía
title	The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
title_short	The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
title_full	The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
title_fullStr	The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
title_full_unstemmed	The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
title_sort	autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation
publishDate	2013
url	http://sedici.unlp.edu.ar/handle/10915/106483 http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3780348&blobtype=pdf
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bdutipo_str	Repositorios
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The autocrine/paracrine loop after myocardial stretch: mineralocorticoid receptor activation

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