Inhalation of marijuana affects <i>Drosophila</i> heart function

We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment prot...

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Detalles Bibliográficos
Autores principales: Gómez, Ivana María, Rodríguez, Maia Abigail, Santalla, Manuela, Kassis, George, Colman Lerner, Jorge Esteban, Aranda Mosquera, Jorge Oswaldo, Sedan, Daniela Yazmine, Andrinolo, Darío, Valverde, Carlos Alfredo, Ferrero, Paola Viviana
Formato: Articulo
Lenguaje:Inglés
Publicado: 2019
Materias:
Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/106330
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-106330
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
spellingShingle Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
Gómez, Ivana María
Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
Inhalation of marijuana affects <i>Drosophila</i> heart function
topic_facet Ciencias Exactas
Ciencias Médicas
Drosophila melanogaster
Cannabis
Cardiac
THC
CBD
Calcium
description We investigated the effect of inhalation of vaporized marijuana on cardiac function in Drosophila melanogaster, a suitable genetic model for studying human diseases. Adult flies were exposed to marijuana for variable time periods and the effects on cardiac function were studied. Short treatment protocol incremented heart-rate variability. Contractility was augmented only under prolonged exposure to cannabis and itwas associated with incremented calcium transient within cardiomyocytes. Neither the activity of the major proteins responsible for calcium handling nor the calcium load of the sarcoplasmic reticulum were affected by the cannabis treatment. The observed changes manifested in the cardiomyocytes even in the absence of the canonical cannabinoid receptors described in mammals. Our results are the first evidence of the in vivo impact of phytocannabinoids in D. melanogaster. By providing a simple and affordable platformprior to mammalian models, this characterization of cardiac function under marijuana exposure opens new paths for conducting genetic screenings using vaporized compounds.
format Articulo
Articulo
author Gómez, Ivana María
Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
author_facet Gómez, Ivana María
Rodríguez, Maia Abigail
Santalla, Manuela
Kassis, George
Colman Lerner, Jorge Esteban
Aranda Mosquera, Jorge Oswaldo
Sedan, Daniela Yazmine
Andrinolo, Darío
Valverde, Carlos Alfredo
Ferrero, Paola Viviana
author_sort Gómez, Ivana María
title Inhalation of marijuana affects <i>Drosophila</i> heart function
title_short Inhalation of marijuana affects <i>Drosophila</i> heart function
title_full Inhalation of marijuana affects <i>Drosophila</i> heart function
title_fullStr Inhalation of marijuana affects <i>Drosophila</i> heart function
title_full_unstemmed Inhalation of marijuana affects <i>Drosophila</i> heart function
title_sort inhalation of marijuana affects <i>drosophila</i> heart function
publishDate 2019
url http://sedici.unlp.edu.ar/handle/10915/106330
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