Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition

The effects of MC-LR on antioxidant system in liver and kidney and its effects on hepatic lipid composition after prolonged exposure to sublethal doses of microcystins (MCs) were studied in mice. Mice were treated i.p. with 25 mg of MC-LR/kg body weight or saline solution every 2 days for a month (i...

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Autores principales: Sedan, Daniela Yazmine, Andrinolo, Darío, Telese, Luis Horacio, Giannuzzi, Leda, Tacconi de Alaniz, María Josefa, Marra, Carlos Alberto
Formato: Articulo
Lenguaje:Inglés
Publicado: 2009
Materias:
Ciencias Exactas
Microcystin
Lipids
Oxidative stress
Antioxidant enzymes
Hepatic damage
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/106324
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-106324
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Microcystin
Lipids
Oxidative stress
Antioxidant enzymes
Hepatic damage
spellingShingle Ciencias Exactas
Microcystin
Lipids
Oxidative stress
Antioxidant enzymes
Hepatic damage
Sedan, Daniela Yazmine
Andrinolo, Darío
Telese, Luis Horacio
Giannuzzi, Leda
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
topic_facet Ciencias Exactas
Microcystin
Lipids
Oxidative stress
Antioxidant enzymes
Hepatic damage
description The effects of MC-LR on antioxidant system in liver and kidney and its effects on hepatic lipid composition after prolonged exposure to sublethal doses of microcystins (MCs) were studied in mice. Mice were treated i.p. with 25 mg of MC-LR/kg body weight or saline solution every 2 days for a month (inflictive stage), then progression or recovery was studied for 1 and 2 months of wash-out. During the inflictive stage, MC-LR-induced oxidative damage and significant changes in liver lipids of treated mice were compared with control mice. A clear dependence of the enzyme defense system was demonstrated with reduced glutathione and a-tocopherol availabilities and a concomitant elevation in NOx production. Sub-chronic MC-LR toxicosis produced alterations in lipid components that included a decreased EFA/non-EFA, SFA/PUFA, and n-3/n-6 ratios all of which exhibited a pattern of slow recovery during the recovery periods.
format Articulo
Articulo
author Sedan, Daniela Yazmine
Andrinolo, Darío
Telese, Luis Horacio
Giannuzzi, Leda
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
author_facet Sedan, Daniela Yazmine
Andrinolo, Darío
Telese, Luis Horacio
Giannuzzi, Leda
Tacconi de Alaniz, María Josefa
Marra, Carlos Alberto
author_sort Sedan, Daniela Yazmine
title Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
title_short Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
title_full Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
title_fullStr Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
title_full_unstemmed Alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-LR in mice: Its relation to liver lipid composition
title_sort alteration and recovery of the antioxidant system induced by sub-chronic exposure to microcystin-lr in mice: its relation to liver lipid composition
publishDate 2009
url http://sedici.unlp.edu.ar/handle/10915/106324
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AT andrinolodario alterationandrecoveryoftheantioxidantsysteminducedbysubchronicexposuretomicrocystinlrinmiceitsrelationtoliverlipidcomposition
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bdutipo_str Repositorios
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