Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation

Data on the impact of the recently recommended maternal pertussis vaccination are promising, but still insufficient to universalise this approach. We thus compared the epidemiological data prior to the implementation of this vaccination strategy in Argentina (2012) with the figures reported after 20...

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Autores principales: Fabricius, Gabriel, Aispuro, Pablo Martín, Bergero, Paula Elena, Bottero, Daniela, Gabrielli, Magalí, Hozbor, Daniela Flavia
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Exactas
Acellular vaccine
Bordetella pertussis
Newborn’s protection
Pertussis
Pregnancy immunisation
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/105051
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-105051
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Acellular vaccine
Bordetella pertussis
Newborn’s protection
Pertussis
Pregnancy immunisation
spellingShingle Ciencias Exactas
Acellular vaccine
Bordetella pertussis
Newborn’s protection
Pertussis
Pregnancy immunisation
Fabricius, Gabriel
Aispuro, Pablo Martín
Bergero, Paula Elena
Bottero, Daniela
Gabrielli, Magalí
Hozbor, Daniela Flavia
Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
topic_facet Ciencias Exactas
Acellular vaccine
Bordetella pertussis
Newborn’s protection
Pertussis
Pregnancy immunisation
description Data on the impact of the recently recommended maternal pertussis vaccination are promising, but still insufficient to universalise this approach. We thus compared the epidemiological data prior to the implementation of this vaccination strategy in Argentina (2012) with the figures reported after 2012. During that 2010–2016 period, two outbreaks occurred, one in 2011 and another in 2016. In the former, the incidence was 6.9/100 000 inhabitants and the casefatality rate 2.6%. Thereafter, a decline in incidence was detected until 2014. During 2015 and 2016 an increase in the incidence transpired, but this rise was fortunately not accompanied by one in the case fatality ratio. Indeed, in 2016 the case fatality ratio was the lowest (0.6%). Moreover, during the 2016 outbreak, the incidence (3.9/100 000 inhabitants) and the case severity detected in the most vulnerable population (infants 0–2 months) were both lower than those in 2011. Consistent with this pattern, in 2016, in the most populated province of Argentina (Buenos Aires), the case percentage with laboratory-positive results indicating a high number of symptoms (59.1% of the total cases) diminished compared with that detected in the 2011 outbreak without maternal immunisation (71.9%). Using the mathematical model of pertussis transmission we previously designed, we assessed the effect of vaccination during pregnancy on infant incidence. From comparisons between the epidemiological data made through calculations, emerged the possibility that vaccinating women during pregnancy would benefit the infants beyond age 2 months, specifically in the 2–12-month cohort.
format Articulo
Articulo
author Fabricius, Gabriel
Aispuro, Pablo Martín
Bergero, Paula Elena
Bottero, Daniela
Gabrielli, Magalí
Hozbor, Daniela Flavia
author_facet Fabricius, Gabriel
Aispuro, Pablo Martín
Bergero, Paula Elena
Bottero, Daniela
Gabrielli, Magalí
Hozbor, Daniela Flavia
author_sort Fabricius, Gabriel
title Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
title_short Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
title_full Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
title_fullStr Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
title_full_unstemmed Pertussis epidemiology in Argentina: TRENDS after the introduction of maternal immunisation
title_sort pertussis epidemiology in argentina: trends after the introduction of maternal immunisation
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/105051
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bdutipo_str Repositorios
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