Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy

Progesterone (P<sub>4</sub>) is a requirement for pregnancy development. Previous reports observed a maximal value of serum P<sub>4</sub> concentration on 21 days after the first mating after which it slowly declines throughout the rest of pregnancy. Ultrasound examination sh...

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Detalles Bibliográficos
Autores principales: García Mitacek, María Carla, Bonaura, María Candela, Praderio, Romina Gisele, Núñez Favre, Romina de los Ángeles, Sota, Rodolfo Luzbel de la, Stornelli, María Alejandra
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Veterinarias
Queen
Pregnancy
Progesterone
Ultrasonography
Aglepristone
Cloprostenol
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104818
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104818
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
Queen
Pregnancy
Progesterone
Ultrasonography
Aglepristone
Cloprostenol
spellingShingle Ciencias Veterinarias
Queen
Pregnancy
Progesterone
Ultrasonography
Aglepristone
Cloprostenol
García Mitacek, María Carla
Bonaura, María Candela
Praderio, Romina Gisele
Núñez Favre, Romina de los Ángeles
Sota, Rodolfo Luzbel de la
Stornelli, María Alejandra
Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
topic_facet Ciencias Veterinarias
Queen
Pregnancy
Progesterone
Ultrasonography
Aglepristone
Cloprostenol
description Progesterone (P<sub>4</sub>) is a requirement for pregnancy development. Previous reports observed a maximal value of serum P<sub>4</sub> concentration on 21 days after the first mating after which it slowly declines throughout the rest of pregnancy. Ultrasound examination should be performed to ensure that pregnancy interruption is complete. Limited information is available on the ultrasonic appearance of conceptuses during pregnancy termination in cats The objective was to study serum P<sub>4</sub> concentration and ultrasonographic changes during aglepristone (ALI) or cloprostenol (CLO) treatment and to evaluate the fertility after treatment. Two experiments (EXP) were carried out to accomplish this aim. Sixty queens, 12- to 36-month-old, were used. On Days 21 to 22 of pregnancy (EXP I) or 35 to 38 of pregnancy (EXP II), queens were divided into three groups (G). Queens in G1 received ALI (10 mg/kg, sc; EXP I, n = 10; EXP II, n = 10) for 2 consecutive days. Queens in G2 received CLO (5 μg/kg, sc; EXP I, n = 10; EXP II = 10) for 3 consecutive days. Queens in G3 received 1 mL of saline solution (PLA, sc; EXP I, n = 10; EXP II = 10). Blood samples were taken before treatment (Day 0) and every day during 10 days after the treatment to measure serum P4 concentrations. Likewise, after treatment, queens were monitored daily by ultrasonography for 10 days and weekly until the end of gestation to obtain gestational sacs measurements (GS), fetal measurements, and fetal biophysical profile. Data were analyzed by ANOVA. Serum P<sub>4</sub> concentrations were significantly different on Day 6 (EXP I) and on Day 1 (EXP II) in ALI and CLO groups compared with PLA group (P < 0.05 and P < 0.01; respectively). The ultrasonographic monitoring during treatment allowed assessing changes in the GS and fetal measurements, embryo-fetal viability, and risk of pregnancy loss. In conclusion, the results from this study reported changes in serum P4 concentration and in ultrasonography measurements during pregnancy interruption with ALI or CLO treatment. Also it was observed that ALI and CLO are safe drugs and can preserve posttreatment queen fertility. Therefore, the results obtained in our work will be applied in feline reproduction practice.
format Articulo
Articulo
author García Mitacek, María Carla
Bonaura, María Candela
Praderio, Romina Gisele
Núñez Favre, Romina de los Ángeles
Sota, Rodolfo Luzbel de la
Stornelli, María Alejandra
author_facet García Mitacek, María Carla
Bonaura, María Candela
Praderio, Romina Gisele
Núñez Favre, Romina de los Ángeles
Sota, Rodolfo Luzbel de la
Stornelli, María Alejandra
author_sort García Mitacek, María Carla
title Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
title_short Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
title_full Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
title_fullStr Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
title_full_unstemmed Progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
title_sort progesterone and ultrasonographic changes during aglepristone or cloprosternol treatment in queens at 21 to 22 or 35 to 38 days of pregnancy
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104818
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