Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)

The aim of the present study was to assess the responses of the gonopodium morphology and the gonadal and liver histology of adult male <i>Cnesterodon decemmaculatus</i> to sublethal long-term exposure concentrations of 17a-ethinylestradiol (EE2). Two experiments were conducted exposing...

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Detalles Bibliográficos
Autores principales: Young, Brian Jonathan, López, Gabriela Carina, Cristos, Diego Sebastián, Crespo, Diana Cristina, Somoza, Gustavo Manuel, Carriquiriborde, Pedro
Formato: Articulo
Lenguaje:Inglés
Publicado: 2016
Materias:
Química
Ciencias Exactas
Ecotoxicology
Estrogenic compounds
Testis-ova
Hepatotoxicity
Cnesterodon decemmaculatus
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104815
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104815
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Ciencias Exactas
Ecotoxicology
Estrogenic compounds
Testis-ova
Hepatotoxicity
Cnesterodon decemmaculatus
spellingShingle Química
Ciencias Exactas
Ecotoxicology
Estrogenic compounds
Testis-ova
Hepatotoxicity
Cnesterodon decemmaculatus
Young, Brian Jonathan
López, Gabriela Carina
Cristos, Diego Sebastián
Crespo, Diana Cristina
Somoza, Gustavo Manuel
Carriquiriborde, Pedro
Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
topic_facet Química
Ciencias Exactas
Ecotoxicology
Estrogenic compounds
Testis-ova
Hepatotoxicity
Cnesterodon decemmaculatus
description The aim of the present study was to assess the responses of the gonopodium morphology and the gonadal and liver histology of adult male <i>Cnesterodon decemmaculatus</i> to sublethal long-term exposure concentrations of 17a-ethinylestradiol (EE2). Two experiments were conducted exposing the fish to waterborne concentrations of EE2 ranging from 20 ng/L to 200 ng/L for 8 wk, 12 wk, and 16 wk. Intersex gonads were observed after 8 wk and 16 wk in fish exposed to 200 ng EE2/L and 100 ng EE2/L, respectively. Oocytes’ development from testis germ cells and replacement of the efferent duct periodic acid-Schiff–positive secretion surrounding spermatozeugmata by parenchymal tissue and duct structure alterations were the major observed changes in the gonads. In contrast, no response was observed in the gonopodium morphology. Liver histology was also altered, showing increasing steatosis, single-cell necrosis to generalized necrosis, and disruption of acinar organization from 100 ng EE2/L to 200 ng EE2/L. In summary, the present results showed that although EE2 was not able to alter the morphology of a developed gonopodium, it was capable of inducing development of testicular oocytes in adult male <i>C. decemmaculatus</i> at environmentally relevant concentrations. Thus, externally normal but intersex <i>C. decemmaculatus</i> males would be expected in the wastewater-receiving streams that the species inhabits. According to the literature, the present study would be the first indicating estrogen-induced intersex in adult male poeciliid.
format Articulo
Articulo
author Young, Brian Jonathan
López, Gabriela Carina
Cristos, Diego Sebastián
Crespo, Diana Cristina
Somoza, Gustavo Manuel
Carriquiriborde, Pedro
author_facet Young, Brian Jonathan
López, Gabriela Carina
Cristos, Diego Sebastián
Crespo, Diana Cristina
Somoza, Gustavo Manuel
Carriquiriborde, Pedro
author_sort Young, Brian Jonathan
title Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
title_short Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
title_full Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
title_fullStr Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
title_full_unstemmed Intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>Cnesterodon decemmaculatus</i> (Pisces: Poeciliidae)
title_sort intersex and liver alterations induced by long‐term sublethal exposure to 17α‐ethinylestradiol in adult male <i>cnesterodon decemmaculatus</i> (pisces: poeciliidae)
publishDate 2016
url http://sedici.unlp.edu.ar/handle/10915/104815
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