Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content

FABP4 is a protein primarily expressed in adipocytes and macrophages that plays a key role in fatty acid trafficking and lipid hydrolysis. FABP4 gene polymorphisms have been associated with meat quality traits in cattle, mostly in Asian breeds under feedlot conditions. The objectives of this work we...

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Autores principales: Goszczynski, Daniel Estanislao, Papaleo Mazzucco, Juliana, Ripoli, María Verónica, Villarreal, Edgardo L., Rogberg Muñoz, Andrés, Mezzadra, Carlos A., Melucci, Lilia M., Giovambattista, Guillermo
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Ciencias Veterinarias
ALBP
Beef
Fatty acid
Meat quality
SNPs
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104792
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104792
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Veterinarias
ALBP
Beef
Fatty acid
Meat quality
SNPs
spellingShingle Ciencias Veterinarias
ALBP
Beef
Fatty acid
Meat quality
SNPs
Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo L.
Rogberg Muñoz, Andrés
Mezzadra, Carlos A.
Melucci, Lilia M.
Giovambattista, Guillermo
Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
topic_facet Ciencias Veterinarias
ALBP
Beef
Fatty acid
Meat quality
SNPs
description FABP4 is a protein primarily expressed in adipocytes and macrophages that plays a key role in fatty acid trafficking and lipid hydrolysis. FABP4 gene polymorphisms have been associated with meat quality traits in cattle, mostly in Asian breeds under feedlot conditions. The objectives of this work were to characterize FABP4 genetic variation in several worldwide cattle breeds and evaluate possible genotype effects on fat content in a pasture-fed crossbred (Angus-Hereford-Limousin) population. We re-sequenced 43 unrelated animals from nine cattle breeds (Angus, Brahman, Creole, Hereford, Holstein, Limousin, Nelore, Shorthorn, and Wagyu) and obtained 22 single nucleotide polymorphisms (SNPs) over 3,164 bp, including four novel polymorphisms. Haplotypes and linkage disequilibrium analyses showed a high variability. Five SNPs were selected to perform validation and association studies in our crossbred population. Four SNPs showed well-balanced allele frequencies (minor frequency > 0.159), and three showed no significant deviations from Hardy-Weinberg proportions. SNPs showed significant effects on backfat thickness and fatty acid composition (P < 0.05). The protein structure of one of the missense SNPs was analyzed to elucidate its possible effect on fat content in our studied population. Our results revealed a possible blockage of the fatty acid binding site by the missense mutation.
format Articulo
Articulo
author Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo L.
Rogberg Muñoz, Andrés
Mezzadra, Carlos A.
Melucci, Lilia M.
Giovambattista, Guillermo
author_facet Goszczynski, Daniel Estanislao
Papaleo Mazzucco, Juliana
Ripoli, María Verónica
Villarreal, Edgardo L.
Rogberg Muñoz, Andrés
Mezzadra, Carlos A.
Melucci, Lilia M.
Giovambattista, Guillermo
author_sort Goszczynski, Daniel Estanislao
title Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
title_short Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
title_full Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
title_fullStr Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
title_full_unstemmed Genetic variation in FABP4 and evaluation of its effects on beef cattle fat content
title_sort genetic variation in fabp4 and evaluation of its effects on beef cattle fat content
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104792
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