A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells

The interaction of oxidovanadium(V) with INHOVA (the condensation product of isoniazid and o-vanillin) lead to the formation of the ester-like complex [VO(INHOVA)EtO(OH2)]Cl·H2O (1). Crystals suitable for X-ray diffraction methods were obtained. The complex crystallizes as a dimer in the space group...

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Detalles Bibliográficos
Autores principales: González Baró, Ana Cecilia, Ferraresi Curotto, Verónica, Pis Diez, Reinaldo, Parajón Costa, Beatriz Susana, Resende, Jackson A. L. C., Paula, Flávia C. S. de, Pereira Maia, Elene C., Rey, Nicolás A.
Formato: Articulo Preprint
Lenguaje:Inglés
Publicado: 2017
Materias:
Química
Cytotoxicity
Isoniazid
O-vanillin
Oxidovanadium(v)
Structural study
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104764
http://hdl.handle.net/11336/50167
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104764
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Química
Cytotoxicity
Isoniazid
O-vanillin
Oxidovanadium(v)
Structural study
spellingShingle Química
Cytotoxicity
Isoniazid
O-vanillin
Oxidovanadium(v)
Structural study
González Baró, Ana Cecilia
Ferraresi Curotto, Verónica
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
Resende, Jackson A. L. C.
Paula, Flávia C. S. de
Pereira Maia, Elene C.
Rey, Nicolás A.
A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
topic_facet Química
Cytotoxicity
Isoniazid
O-vanillin
Oxidovanadium(v)
Structural study
description The interaction of oxidovanadium(V) with INHOVA (the condensation product of isoniazid and o-vanillin) lead to the formation of the ester-like complex [VO(INHOVA)EtO(OH2)]Cl·H2O (1). Crystals suitable for X-ray diffraction methods were obtained. The complex crystallizes as a dimer in the space group P21/c of the monoclinic system. A detailed analysis, including solid-state vibrational spectroscopy and electronic spectroscopy in DMSO solution, was performed for both INHOVA and complex (1). A complete theoretical study based on DFT was also carried out. The calculations were of valuable assistance in the spectra assignments and interpretation. The electrochemical characterization allows determining the redox behavior of INHOVA and complex (1). Cytotoxicity was assayed against the chronic myelogenous leukemia K562 cell line. The IC50 values obtained denote that both the ligand and complex (1) are good candidates for further studies.
format Articulo
Preprint
author González Baró, Ana Cecilia
Ferraresi Curotto, Verónica
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
Resende, Jackson A. L. C.
Paula, Flávia C. S. de
Pereira Maia, Elene C.
Rey, Nicolás A.
author_facet González Baró, Ana Cecilia
Ferraresi Curotto, Verónica
Pis Diez, Reinaldo
Parajón Costa, Beatriz Susana
Resende, Jackson A. L. C.
Paula, Flávia C. S. de
Pereira Maia, Elene C.
Rey, Nicolás A.
author_sort González Baró, Ana Cecilia
title A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
title_short A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
title_full A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
title_fullStr A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
title_full_unstemmed A novel oxidovanadium(V) compound with an isonicotinohydrazide ligand: A combined experimental and theoretical study and cytotoxity against K562 cells
title_sort novel oxidovanadium(v) compound with an isonicotinohydrazide ligand: a combined experimental and theoretical study and cytotoxity against k562 cells
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104764
http://hdl.handle.net/11336/50167
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