Perinatal Programming of Circadian Clock-Stress Crosstalk

An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both - from the systemic to the molecular le...

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Detalles Bibliográficos
Autores principales: Astiz, Mariana, Oster, Henrik
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Medicina
development
circadian clock
stress axis
programming
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104758
http://hdl.handle.net/11336/96709
https://www.hindawi.com/journals/np/2018/5689165/
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104758
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Medicina
development
circadian clock
stress axis
programming
spellingShingle Medicina
development
circadian clock
stress axis
programming
Astiz, Mariana
Oster, Henrik
Perinatal Programming of Circadian Clock-Stress Crosstalk
topic_facet Medicina
development
circadian clock
stress axis
programming
description An intact communication between circadian clocks and the stress system is important for maintaining physiological homeostasis under resting conditions and in response to external stimuli. There is accumulating evidence for a reciprocal interaction between both - from the systemic to the molecular level. Disruption of this interaction by external factors such as shiftwork, jetlag, or chronic stress increases the risk of developing metabolic, immune, or mood disorders. From experiments in rodents, we know that both systems maturate during the perinatal period. During that time, exogenous factors such as stress or alterations in the external photoperiod may critically affect - or program - physiological functions later in life. This developmental programming process has been attributed to maternal stress signals reaching the embryo, which lastingly change gene expression through the induction of epigenetic mechanisms. Despite the well-known function of the adult circadian system in temporal coordination of physiology and behavior, the role of maternal and embryonic circadian clocks during pregnancy and postnatal development is still poorly defined. A better understanding of the circadian-stress crosstalk at different periods of development may help to improve stress resistance and devise preventive and therapeutic strategies against chronic stress-associated disorders.
format Articulo
Articulo
author Astiz, Mariana
Oster, Henrik
author_facet Astiz, Mariana
Oster, Henrik
author_sort Astiz, Mariana
title Perinatal Programming of Circadian Clock-Stress Crosstalk
title_short Perinatal Programming of Circadian Clock-Stress Crosstalk
title_full Perinatal Programming of Circadian Clock-Stress Crosstalk
title_fullStr Perinatal Programming of Circadian Clock-Stress Crosstalk
title_full_unstemmed Perinatal Programming of Circadian Clock-Stress Crosstalk
title_sort perinatal programming of circadian clock-stress crosstalk
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/104758
http://hdl.handle.net/11336/96709
https://www.hindawi.com/journals/np/2018/5689165/
work_keys_str_mv AT astizmariana perinatalprogrammingofcircadianclockstresscrosstalk
AT osterhenrik perinatalprogrammingofcircadianclockstresscrosstalk
bdutipo_str Repositorios
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