Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found th...
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| Autores principales: | , , |
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| Formato: | Articulo |
| Lenguaje: | Inglés |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | http://sedici.unlp.edu.ar/handle/10915/104747 http://hdl.handle.net/11336/50200 https://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.html |
| Aporte de: |
| Sumario: | The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized. |
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