Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line

The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found th...

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Detalles Bibliográficos
Autores principales: León, Ignacio Esteban, Etcheverry, Susana Beatriz, Baran, Enrique José
Formato: Articulo
Lenguaje:Inglés
Publicado: 2015
Materias:
Ciencias Exactas
Química
oxidovanadium(IV)
dipyrido[3,2-a:2',3'-c]phenazine (dppz)
metallointercalators
human osteosarcoma cell line
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104747
http://hdl.handle.net/11336/50200
https://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.html
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104747
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Exactas
Química
oxidovanadium(IV)
dipyrido[3,2-a:2',3'-c]phenazine (dppz)
metallointercalators
human osteosarcoma cell line
spellingShingle Ciencias Exactas
Química
oxidovanadium(IV)
dipyrido[3,2-a:2',3'-c]phenazine (dppz)
metallointercalators
human osteosarcoma cell line
León, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
topic_facet Ciencias Exactas
Química
oxidovanadium(IV)
dipyrido[3,2-a:2',3'-c]phenazine (dppz)
metallointercalators
human osteosarcoma cell line
description The cytotoxicity activity of the recently reported [VO(H<sub>2</sub>O)<sub>2</sub>(SO<sub>4</sub>)dppz]·2H<sub>2</sub>O complex (dppz = dipyrido[3,2-a:2',3'- c]phenazine) on MG-63 human osteosarcoma cell line was investigated. It was found that it caused a concentration related inhibitory effect in the concentration range between 5 and 25 µM and diminished the cell viability ca. 40% in the range from 25 to 100 µM, without dose/response effects in this range. These biological effects are, in general, similar to those previously reported for the related [VO(ODA)dppz]·3H<sub>2</sub>O (ODA = dianion of oxodiacetic acid) and [VO(ODA)(phen)]·1.5H<sub>2</sub>O (phen = o- phenanthroline) complexes. The importance of the presence of DNAintercalating ligands in these complexes is emphasized.
format Articulo
Articulo
author León, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
author_facet León, Ignacio Esteban
Etcheverry, Susana Beatriz
Baran, Enrique José
author_sort León, Ignacio Esteban
title Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_short Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_full Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_fullStr Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_full_unstemmed Cytotoxicity action of an oxidovanadium(IV)-DPPZ complex on MG-63 human osteosarcoma cell line
title_sort cytotoxicity action of an oxidovanadium(iv)-dppz complex on mg-63 human osteosarcoma cell line
publishDate 2015
url http://sedici.unlp.edu.ar/handle/10915/104747
http://hdl.handle.net/11336/50200
https://www.tsijournals.com/abstract/cytotoxicity-action-of-an-oxidovanadiumivdppz-complex-on-mg63-human-osteosarcoma-cell-line-2208.html
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AT etcheverrysusanabeatriz cytotoxicityactionofanoxidovanadiumivdppzcomplexonmg63humanosteosarcomacellline
AT baranenriquejose cytotoxicityactionofanoxidovanadiumivdppzcomplexonmg63humanosteosarcomacellline
bdutipo_str Repositorios
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