Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia

Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neurodegenerative markers increases in CA1 hippocampa...

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Autores principales: Saraceno, Gustavo Ezequiel, Bellini, María José, García Segura, Luis Miguel, Capani, Francisco
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Hippocampus
Neuronal survival
Neuroprotection
Signaling pathway
Western blot
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104737
http://hdl.handle.net/11336/99309
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104737
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Hippocampus
Neuronal survival
Neuroprotection
Signaling pathway
Western blot
spellingShingle Ciencias Médicas
Hippocampus
Neuronal survival
Neuroprotection
Signaling pathway
Western blot
Saraceno, Gustavo Ezequiel
Bellini, María José
García Segura, Luis Miguel
Capani, Francisco
Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
topic_facet Ciencias Médicas
Hippocampus
Neuronal survival
Neuroprotection
Signaling pathway
Western blot
description Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neurodegenerative markers increases in CA1 hippocampal area of 4-months-old male rats born by cesarean section and exposed for 19 min to PA. We have also shown that a late treatment with 17β estradiol (daily dose of 250 μg/kg for 3 days) was able to revert the brain alterations observed in those animals. Based on these previous results, the main aim of the present study was to explore the mechanism by which the estrogenic treatment is involved in the reversion of the chronic neurodegenerative conditions induced by PA. We demonstrated that estradiol treatment of adult PA exposed animals induced an increase in estrogen receptor (ER) a and insulin-like growth factor receptor (IGF-1R) protein levels, an activation of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 beta/β-catenin signaling pathway and an increase in Bcl-2/Bax ratio in the hippocampus in comparison to PA exposed animals treated with vehicle. Taking together, our data suggest that the interaction between ERa and IGF-IR, with the subsequent downstream activation, underlies the beneficial effects of estradiol observed in late treatment of PA.
format Articulo
Articulo
author Saraceno, Gustavo Ezequiel
Bellini, María José
García Segura, Luis Miguel
Capani, Francisco
author_facet Saraceno, Gustavo Ezequiel
Bellini, María José
García Segura, Luis Miguel
Capani, Francisco
author_sort Saraceno, Gustavo Ezequiel
title Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
title_short Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
title_full Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
title_fullStr Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
title_full_unstemmed Estradiol activates PI3K/Akt/GSK3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
title_sort estradiol activates pi3k/akt/gsk3 pathway under chronic neurodegenerative conditions triggered by perinatal asphyxia
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/104737
http://hdl.handle.net/11336/99309
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AT garciaseguraluismiguel estradiolactivatespi3kaktgsk3pathwayunderchronicneurodegenerativeconditionstriggeredbyperinatalasphyxia
AT capanifrancisco estradiolactivatespi3kaktgsk3pathwayunderchronicneurodegenerativeconditionstriggeredbyperinatalasphyxia
bdutipo_str Repositorios
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