Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour

Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l...

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Detalles Bibliográficos
Autores principales:	Loiola, Lívia M. D., Cortez Tornello, Pablo Roberto, Abraham, Gustavo Abel, Felisberti, Maria I.
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2017
Materias:	Ingeniería Química Electrospinning Amphiphilic copolymers Drug release
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/104640 http://hdl.handle.net/11336/64134
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-104640
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Ingeniería Química Electrospinning Amphiphilic copolymers Drug release
spellingShingle	Ingeniería Química Electrospinning Amphiphilic copolymers Drug release Loiola, Lívia M. D. Cortez Tornello, Pablo Roberto Abraham, Gustavo Abel Felisberti, Maria I. Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
topic_facet	Ingeniería Química Electrospinning Amphiphilic copolymers Drug release
description	Biocompatible amphiphilic copolymers are attractive candidates for the fabrication of electrospun scaffolds to be used for tissue engineering and the delivery of biologically active compounds. The amphiphilic block copolymers poly(l-lactide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PELA) and poly(l-lactide)-b-poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide)-b-poly(l-lactide) (PEPELA), which contain amorphous/crystalline and hydrophilic/hydrophobic blocks, were synthesized by ring-opening polymerization, and then electrospun to obtain non-woven fibrous scaffolds. Acetaminophen (AC) and celecoxib (CL) were used as hydrophilic and hydrophobic model drugs, respectively, to prepare drug-loaded scaffolds. The pure and drug-loaded scaffolds present a morphology characterized by randomly oriented fibres with integrated beads. The drug encapsulation and release profiles were determined by ultraviolet-visible spectroscopy. Due to the amphiphilic nature of PELA and PEPELA, both hydrophilic and hydrophobic drugs could be entrapped within the polymeric scaffolds, allowing the design of drug-delivery systems for specific applications. The combination of confocal Raman spectroscopy mapping and dynamic mechanical analysis revealed that the AC drug is preferentially maintained in the PEO phase, while the CL drug is fractionated between polyether and polyester phases and distributed throughout the fibrous structure due to its hydrophobic character.
format	Articulo Preprint
author	Loiola, Lívia M. D. Cortez Tornello, Pablo Roberto Abraham, Gustavo Abel Felisberti, Maria I.
author_facet	Loiola, Lívia M. D. Cortez Tornello, Pablo Roberto Abraham, Gustavo Abel Felisberti, Maria I.
author_sort	Loiola, Lívia M. D.
title	Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_short	Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_full	Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_fullStr	Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_full_unstemmed	Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour
title_sort	amphiphilic electrospun scaffolds of plla-peo-ppo block copolymers: preparation, characterization and drug-release behaviour
publishDate	2017
url	http://sedici.unlp.edu.ar/handle/10915/104640 http://hdl.handle.net/11336/64134
work_keys_str_mv	AT loiolaliviamd amphiphilicelectrospunscaffoldsofpllapeoppoblockcopolymerspreparationcharacterizationanddrugreleasebehaviour AT corteztornellopabloroberto amphiphilicelectrospunscaffoldsofpllapeoppoblockcopolymerspreparationcharacterizationanddrugreleasebehaviour AT abrahamgustavoabel amphiphilicelectrospunscaffoldsofpllapeoppoblockcopolymerspreparationcharacterizationanddrugreleasebehaviour AT felisbertimariai amphiphilicelectrospunscaffoldsofpllapeoppoblockcopolymerspreparationcharacterizationanddrugreleasebehaviour
bdutipo_str	Repositorios
_version_	1764820442133037058

Amphiphilic electrospun scaffolds of PLLA-PEO-PPO block copolymers: preparation, characterization and drug-release behaviour

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