Development shapes a consistent inbreeding effect in mouse crania of different line crosses

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Development translates genetic variation into a multivariate pattern of phenotypic variation, distributing it among traits in a nonuniform manner. As developmental processes are largely shared within species, this suggests that heritable phenotypic variation will be patterned similarly, in spite of...

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Autores principales:	Pavličev, Mihaela, Mitteroecker, Philipp, González, Paula Natalia, Rolian, Campbell, Jamniczky, Heather, Villena, Fernando Pardo Manuel, Marcucio, Ralph, Spritz, Richard, Hallgrimsson, Benedikt
Formato:	Articulo Preprint
Lenguaje:	Inglés
Publicado:	2016
Materias:	Biología Differential dominance Developmental constraint Pleiotropy Integration Multivariate quantitative genetics
Acceso en línea:	http://sedici.unlp.edu.ar/handle/10915/104637 http://hdl.handle.net/11336/55177 https://onlinelibrary.wiley.com/doi/abs/10.1002/jez.b.22722
Aporte de:	SEDICI (UNLP) de Universidad Nacional de La Plata

id	I19-R120-10915-104637
record_format	dspace
institution	Universidad Nacional de La Plata
institution_str	I-19
repository_str	R-120
collection	SEDICI (UNLP)
language	Inglés
topic	Biología Differential dominance Developmental constraint Pleiotropy Integration Multivariate quantitative genetics
spellingShingle	Biología Differential dominance Developmental constraint Pleiotropy Integration Multivariate quantitative genetics Pavličev, Mihaela Mitteroecker, Philipp González, Paula Natalia Rolian, Campbell Jamniczky, Heather Villena, Fernando Pardo Manuel Marcucio, Ralph Spritz, Richard Hallgrimsson, Benedikt Development shapes a consistent inbreeding effect in mouse crania of different line crosses
topic_facet	Biología Differential dominance Developmental constraint Pleiotropy Integration Multivariate quantitative genetics
description	Development translates genetic variation into a multivariate pattern of phenotypic variation, distributing it among traits in a nonuniform manner. As developmental processes are largely shared within species, this suggests that heritable phenotypic variation will be patterned similarly, in spite of the different segregating alleles. To investigate developmental effect on the variational pattern in the shape of the mouse skull across genetically differentiated lines, we employed the full set of reciprocal crosses (a.k.a. diallel) between eight inbred mouse strains of the Collaborative Cross Project. We used geometric morphometrics and multivariate analysis to capture cranial size and shape changes in 8 parentals and their 54 F1 crosses. The high heterozygosity generated in the F1 crosses allowed us to compare the multivariate deviations of the F1 phenotypes from the expected midparental phenotypes in different haplotype combinations. In contrast to body weight, we found a high degree of nonadditive deviation in craniofacial shape. Whereas the phenotypic and genetic divergence of parental strains manifested in high dimensionality of additive effects, the nonadditive deviations exhibited lesser dimensionality and in particular a strikingly coherent direction in shape space. We interpret this finding as evidence for a strong structuring effect of a relatively small set of developmental processes on the mapping of genetic to phenotypic variation.
format	Articulo Preprint
author	Pavličev, Mihaela Mitteroecker, Philipp González, Paula Natalia Rolian, Campbell Jamniczky, Heather Villena, Fernando Pardo Manuel Marcucio, Ralph Spritz, Richard Hallgrimsson, Benedikt
author_facet	Pavličev, Mihaela Mitteroecker, Philipp González, Paula Natalia Rolian, Campbell Jamniczky, Heather Villena, Fernando Pardo Manuel Marcucio, Ralph Spritz, Richard Hallgrimsson, Benedikt
author_sort	Pavličev, Mihaela
title	Development shapes a consistent inbreeding effect in mouse crania of different line crosses
title_short	Development shapes a consistent inbreeding effect in mouse crania of different line crosses
title_full	Development shapes a consistent inbreeding effect in mouse crania of different line crosses
title_fullStr	Development shapes a consistent inbreeding effect in mouse crania of different line crosses
title_full_unstemmed	Development shapes a consistent inbreeding effect in mouse crania of different line crosses
title_sort	development shapes a consistent inbreeding effect in mouse crania of different line crosses
publishDate	2016
url	http://sedici.unlp.edu.ar/handle/10915/104637 http://hdl.handle.net/11336/55177 https://onlinelibrary.wiley.com/doi/abs/10.1002/jez.b.22722
work_keys_str_mv	AT pavlicevmihaela developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT mitteroeckerphilipp developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT gonzalezpaulanatalia developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT roliancampbell developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT jamniczkyheather developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT villenafernandopardomanuel developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT marcucioralph developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT spritzrichard developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses AT hallgrimssonbenedikt developmentshapesaconsistentinbreedingeffectinmousecraniaofdifferentlinecrosses
bdutipo_str	Repositorios
_version_	1764820442128842752

Development shapes a consistent inbreeding effect in mouse crania of different line crosses

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