A historical legacy of antibiotic utilization on bacterial seed banks in sediments

The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these c...

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Autores principales: Madueño, Laura, Paul, Christophe, Junier, Thomas, Bayrychenko, Zhanna, Filippidou, Sevasti, Beck, Karin, Greub, Gilbert, Bürgmann, Helmut, Junier, Pilar
Formato: Articulo
Lenguaje:Inglés
Publicado: 2018
Materias:
Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104623
http://hdl.handle.net/11336/93894
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104623
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
spellingShingle Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
A historical legacy of antibiotic utilization on bacterial seed banks in sediments
topic_facet Ciencias Médicas
Ciencias Exactas
Antibiotic resistance
Clostridia
Endospores
Sediments
Seed bank
Sulfonamide
Tetracycline
description The introduction of antibiotics for both medical and non-medical purposes has had a positive effect on human welfare and agricultural output in the past century. However, there is also an important ecological legacy regarding the use of antibiotics and the consequences of increased levels of these compounds in the environment as a consequence of their use and disposal. This legacy was investigated by quantifying two antibiotic resistance genes (ARG) conferring resistance to tetracycline (<i>tet</i>(W)) and sulfonamide (<i>sul</i>1) in bacterial seed bank DNA in sediments. The industrial introduction of antibiotics caused an abrupt increase in the total abundance of <i>tet</i>(W) and a steady increase in sul1. The abrupt change in <i>tet</i>(W) corresponded to an increase in relative abundance from ca. 1960 that peaked around 1976. This pattern of accumulation was highly correlated with the abundance of specific members of the seed bank community belonging to the phylum <i>Firmicutes</i>. In contrast, the relative abundance of <i>sul</i>1 increased after 1976. This correlated with a taxonomically broad spectrum of bacteria, reflecting <i>sul</i>1 dissemination through horizontal gene transfer. The accumulation patterns of both ARGs correspond broadly to the temporal scale of medical antibiotic use. Our results show that the bacterial seed bank can be used to look back at the historical usage of antibiotics and resistance prevalence.
format Articulo
Articulo
author Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author_facet Madueño, Laura
Paul, Christophe
Junier, Thomas
Bayrychenko, Zhanna
Filippidou, Sevasti
Beck, Karin
Greub, Gilbert
Bürgmann, Helmut
Junier, Pilar
author_sort Madueño, Laura
title A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_short A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_fullStr A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_full_unstemmed A historical legacy of antibiotic utilization on bacterial seed banks in sediments
title_sort historical legacy of antibiotic utilization on bacterial seed banks in sediments
publishDate 2018
url http://sedici.unlp.edu.ar/handle/10915/104623
http://hdl.handle.net/11336/93894
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