Rodent models for the analysis of tissue clock function in metabolic rhythms research

The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level. Genetic and non-genetic approaches in rodents have been emp...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsang, Anthony H., Astiz, Mariana, Leinweber, Brinja, Oster, Henrik
Formato: Articulo
Lenguaje:Inglés
Publicado: 2017
Materias:
Biología
Ciencias Médicas
Bmal1
Clock genes
Conditional knockout
CRE-loxP system
Gene targeting
Metabolism
Acceso en línea:http://sedici.unlp.edu.ar/handle/10915/104612
http://hdl.handle.net/11336/48627
Aporte de:
SEDICI (UNLP) de Universidad Nacional de La Plata
id I19-R120-10915-104612
record_format dspace
institution Universidad Nacional de La Plata
institution_str I-19
repository_str R-120
collection SEDICI (UNLP)
language Inglés
topic Biología
Ciencias Médicas
Bmal1
Clock genes
Conditional knockout
CRE-loxP system
Gene targeting
Metabolism
spellingShingle Biología
Ciencias Médicas
Bmal1
Clock genes
Conditional knockout
CRE-loxP system
Gene targeting
Metabolism
Tsang, Anthony H.
Astiz, Mariana
Leinweber, Brinja
Oster, Henrik
Rodent models for the analysis of tissue clock function in metabolic rhythms research
topic_facet Biología
Ciencias Médicas
Bmal1
Clock genes
Conditional knockout
CRE-loxP system
Gene targeting
Metabolism
description The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level. Genetic and non-genetic approaches in rodents have been employed to study circadian clock function in the living organism. Due to the ubiquitous expression of clock genes and the intricate interaction between the circadian system and energy metabolism, genetic approaches targeting specific tissue clocks have been used to assess their contribution in systemic metabolic processes. However, special requirements regarding specificity and efficiency have to be met to allow for valid conclusions from such studies. In this review, we provide a brief summary of different approaches developed for dissecting tissue clock function in the metabolic context in rodents, compare their strengths and weaknesses, and suggest new strategies in assessing tissue clock output and the consequences of circadian clock disruption in vivo.
format Articulo
Articulo
author Tsang, Anthony H.
Astiz, Mariana
Leinweber, Brinja
Oster, Henrik
author_facet Tsang, Anthony H.
Astiz, Mariana
Leinweber, Brinja
Oster, Henrik
author_sort Tsang, Anthony H.
title Rodent models for the analysis of tissue clock function in metabolic rhythms research
title_short Rodent models for the analysis of tissue clock function in metabolic rhythms research
title_full Rodent models for the analysis of tissue clock function in metabolic rhythms research
title_fullStr Rodent models for the analysis of tissue clock function in metabolic rhythms research
title_full_unstemmed Rodent models for the analysis of tissue clock function in metabolic rhythms research
title_sort rodent models for the analysis of tissue clock function in metabolic rhythms research
publishDate 2017
url http://sedici.unlp.edu.ar/handle/10915/104612
http://hdl.handle.net/11336/48627
work_keys_str_mv AT tsanganthonyh rodentmodelsfortheanalysisoftissueclockfunctioninmetabolicrhythmsresearch
AT astizmariana rodentmodelsfortheanalysisoftissueclockfunctioninmetabolicrhythmsresearch
AT leinweberbrinja rodentmodelsfortheanalysisoftissueclockfunctioninmetabolicrhythmsresearch
AT osterhenrik rodentmodelsfortheanalysisoftissueclockfunctioninmetabolicrhythmsresearch
bdutipo_str Repositorios
_version_ 1764820442092142593

Ejemplares similares